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NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients.
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- Author(s): Malhotra, Sunny1; Sorosina, Melissa2; Río, Jordi1; Peroni, Silvia2; Midaglia, Luciana1; Villar, Luisa M.3; Álvarez-Cermeño, José C.3; Schroeder, Ina4; Esposito, Federica5; Clarelli, Ferdinando2; Zettl, Uwe K.4; Lechner-Scott, Jeannette6; Spataro, Nino7; Navarro, Arcadi8; Comi, Giancarlo9; Montalban, Xavier1; Martinelli-Boneschi, Filippo10; Comabella, Manuel1
- Source:
Multiple Sclerosis Journal. Oct2018, Vol. 24 Issue 11, p1507-1510. 4p. 2 Charts.
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- Additional Information
- Abstract:
We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients. [ABSTRACT FROM AUTHOR]
- Abstract:
Copyright of Multiple Sclerosis Journal is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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