TAFRO syndrome complicated with occlusion of multiple cerebral arteries.

Thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly (TAFRO) syndrome is a recently proposed disease entity that is considered to be a variant of Castleman's disease. Here, we report a 42-year-old woman with fever, pleural effusion, massive ascites, severe oedema, hepatosplenomegaly, renal failure and thrombocytopenia who developed broad cerebral infarction with severe stenoses of the bilateral internal carotid arteries during the early course of treatment. To our knowledge, this is the first report of TAFRO syndrome with severe cerebral infarction, which suggests cerebral artery vasculitis. [ABSTRACT FROM AUTHOR]