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Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia.
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- Author(s): Oh, Esther S.; Blennow, Kaj; Bigelow, George E.; Inouye, Sharon K.; Marcantonio, Edward R.; Neufeld, Karin J.; Rosenberg, Paul B.; Troncoso, Juan C.; Wang, Nae-Yuh; Zetterberg, Henrik; Sieber, Frederick E.; Lyketsos, Constantine G.
- Source:
PLoS ONE; 9/25/2018, Vol. 13 Issue 9, p1-10, 10p- Subject Terms:
- Source:
- Additional Information
- Abstract: Background: There is strong association of Alzheimer’s disease (AD) pathology with gait disorder and falls in older adults without dementia. The goal of the study was to examine the prevalence and severity of AD pathology in older adults without dementia who fall and sustain hip fracture. Methods: Cerebrospinal fluid (CSF) was obtained from 168 hip fracture patients. CSF Aβ42/40 ratio, p-tau, and t-tau measures were dichotomized into normal vs. abnormal, and categorized according to the A/T/N classification. Results: Among the hip fracture patients, 88.6% of the cognitively normal (Clinical Dementia Rating-CDR 0; n = 70) and 98.8% with mild cognitive impairment (CDR 0.5; n = 81) fell in the abnormal biomarker categories by the A/T/N classification. Conclusions: A large proportion of older hip fracture patients have CSF evidence of AD pathology. Preoperative determination of AD biomarkers may play a crucial role in identifying persons without dementia who have underlying AD pathology in perioperative settings. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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