Topological Properties of the Structural Brain Network in Autism via ϵ-Neighbor Method.

AUTISM; DIFFUSION tensor imaging; DIFFUSION magnetic resonance imaging; AUTISM spectrum disorders; DEVELOPMENTAL disabilities

Objective: Topological characteristics of the brain can be analyzed using structural brain networks constructed by diffusion tensor imaging (DTI). When a brain network is constructed by the existing parcellation method, the structure of the network changes depending on the scale of parcellation and arbitrary thresholding. To overcome these issues, we propose to construct brain networks using the improved $\varepsilon $ -neighbor construction, which is a parcellation free network construction technique. Methods: We acquired DTI from 14 control subjects and 15 subjects with autism. We examined the differences in topological properties of the brain networks constructed using the proposed method and the existing parcellation between the two groups. Results: As the number of nodes increased, the connectedness of the network decreased in the parcellation method. However, for brain networks constructed using the proposed method, connectedness remained at a high level even with an increase in the number of nodes. We found significant differences in several topological properties of brain networks constructed using the proposed method, whereas topological properties were not significantly different for the parcellation method. Conclusion: The brain networks constructed using the proposed method are considered as more realistic than a parcellation method with respect to the stability of connectedness. We found that subjects with autism showed the abnormal characteristics in the brain networks. These results demonstrate that the proposed method may provide new insights to analysis in the structural brain network. Significance: We proposed the novel brain network construction method to overcome the shortcoming in the existing parcellation method. [ABSTRACT FROM AUTHOR]

Copyright of IEEE Transactions on Biomedical Engineering is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)