Localization of binding sites for atrial natriuretic factor and angiotensin II in the central nervous system of the clawed toad Xenopus laevis.

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  • Author(s): Kloas W;Kloas W; Hanke W
  • Source:
    Cell and tissue research [Cell Tissue Res] 1992 Feb; Vol. 267 (2), pp. 365-73.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417625 Publication Model: Print Cited Medium: Print ISSN: 0302-766X (Print) Linking ISSN: 0302766X NLM ISO Abbreviation: Cell Tissue Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin, New York, Springer-Verlag.
    • Subject Terms:
      Brain Chemistry*; Angiotensin II/*metabolism ; Atrial Natriuretic Factor/*metabolism ; Receptors, Angiotensin/*analysis ; Receptors, Cell Surface/*analysis ; Xenopus laevis/*metabolism; Angiotensin II/physiology ; Animals ; Atrial Natriuretic Factor/physiology ; Binding, Competitive ; Brain/anatomy & histology ; Brain Mapping ; Receptors, Angiotensin/metabolism ; Receptors, Atrial Natriuretic Factor ; Receptors, Cell Surface/metabolism ; Xenopus laevis/anatomy & histology
    • Abstract:
      The distribution of binding sites for atrial natriuretic factor (ANF) and angiotensin II (A II) was investigated in the central nervous system (CNS) of the clawed toad Xenopus laevis by means of in vitro autoradiography using [125I]-rat ANF(99-126) or [125I] [Val5] A II and [125I]human A II as labeled ligands. The highest densities of specific ANF-binding were detected in the nucleus habenularis, thalamic regions, hypophyseal pars nervosa and nucleus interpeduncularis. Moderate ANF-binding was found in the bulbus olfactorius, pallium, septum, striatum, lateral forebrain bundle, nucleus infundibularis, hypophyseal pars distalis and tectum. The highest levels of specific A II binding sites were observed in the nucleus praeopticus, nucleus habenularis, hypophyseal pars nervosa and pars distalis, whereas the amygdala contained moderate A II binding. The existence of specific binding sites for ANF and A II in the CNS of Xenopus laevis suggests that both peptides act as neurotransmitters or neuromodulators in the amphibian CNS. The co-localization of dense binding sites for both peptides in the nucleus habenularis, hypophyseal pars nervosa and pars distalis supports the view that ANF and A II have opposite regulatory functions in these regions.
    • References:
      Proc Natl Acad Sci U S A. 1984 Oct;81(20):6325-9. (PMID: 6238331)
      Gen Comp Endocrinol. 1987 Oct;68(1):19-27. (PMID: 2822525)
      Peptides. 1986 Jul-Aug;7(4):573-9. (PMID: 2945164)
      Peptides. 1986 Jul-Aug;7(4):679-87. (PMID: 3763440)
      Proc Natl Acad Sci U S A. 1986 Jan;83(1):174-8. (PMID: 3001722)
      J Cardiovasc Pharmacol. 1984;6 Suppl 4:S575-86. (PMID: 6083400)
      Regul Pept. 1985 Jul;11(3):237-43. (PMID: 2997859)
      Biochem Biophys Res Commun. 1985 Aug 15;130(3):981-6. (PMID: 3161512)
      Peptides. 1985;6 Suppl 3:321-31. (PMID: 3841692)
      Peptides. 1984 Nov-Dec;5(6):1167-72. (PMID: 6241671)
      Biochem Biophys Res Commun. 1986 Mar 28;135(3):1035-41. (PMID: 3008738)
      Endocrinology. 1981 Sep;109(3):893-9. (PMID: 7262024)
      Clin Physiol Biochem. 1988;6(3-4):163-70. (PMID: 2974327)
      Cell Mol Neurobiol. 1987 Jun;7(2):151-73. (PMID: 2820578)
      Regul Pept. 1987 Jan;17(1):53-60. (PMID: 3031746)
      Rev Physiol Biochem Pharmacol. 1988;110:1-145. (PMID: 2835808)
      FEBS Lett. 1988 Oct 10;238(2):300-6. (PMID: 2971573)
      Am J Physiol. 1984 Jul;247(1 Pt 2):R34-9. (PMID: 6540055)
      Biochem Biophys Res Commun. 1985 Nov 15;132(3):1088-94. (PMID: 2934060)
      Endocr Rev. 1984 Winter;5(1):45-61. (PMID: 6368215)
      J Comp Neurol. 1989 Mar 15;281(3):384-96. (PMID: 2522951)
      J Pharmacol Methods. 1984 Apr;11(2):137-50. (PMID: 6717031)
      Adv Biochem Psychopharmacol. 1981;28:359-72. (PMID: 6259907)
      Peptides. 1987 May-Jun;8(3):449-54. (PMID: 2958784)
      Endocrinology. 1989 Jun;124(6):2799-808. (PMID: 2542000)
      Endocrinology. 1984 Nov;115(5):2026-8. (PMID: 6092045)
      Gen Comp Endocrinol. 1992 May;86(2):173-83. (PMID: 1601265)
      Biochem Biophys Res Commun. 1988 Sep 30;155(3):1338-45. (PMID: 2972279)
      Gen Comp Endocrinol. 1992 Jan;85(1):26-35. (PMID: 1532947)
      Biochem Biophys Res Commun. 1984 Dec 28;125(3):938-46. (PMID: 6542779)
      J Neurosci Methods. 1988 Aug;25(1):75-82. (PMID: 2851688)
      Endocrinology. 1989 Apr;124(4):1774-80. (PMID: 2647465)
      Neuroscience. 1987 Jul;22(1):341-59. (PMID: 2957610)
      Am J Physiol. 1986 Oct;251(4 Pt 2):F594-602. (PMID: 2945442)
    • Accession Number:
      0 (Receptors, Angiotensin)
      0 (Receptors, Cell Surface)
      11128-99-7 (Angiotensin II)
      85637-73-6 (Atrial Natriuretic Factor)
      EC 4.6.1.2 (Receptors, Atrial Natriuretic Factor)
    • Publication Date:
      Date Created: 19920201 Date Completed: 19920713 Latest Revision: 20190720
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/BF00302975
    • Accession Number:
      1318168