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Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria.
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- Author(s): Costa, Pedro A C; Figueiredo, Maria M; Diniz, Suelen Q; Peixoto, Ana P M M; Maloy, Kevin J; Teixeira-Carvalho, Andréa; Tada, Mauro S; Pereira, Dhelio B; Gazzinelli, Ricardo T; Antonelli, Lis R V
- Source:
Journal of Infectious Diseases; 10/15/2018, Vol. 218 Issue 8, p1314-1323, 10p- Subject Terms:
- Source:
- Additional Information
- Abstract: The balance between pro- and antiinflammatory mechanisms is essential to limit immune-mediated pathology, and CD4+ forkhead box P3 (Foxp3+) regulatory T cells (Treg) play an important role in this process. The expression of inhibitory receptors regulates cytokine production by Plasmodium vivax-specific T cells. Our goal was to assess the induction of programmed death-1 (PD-1) and cytotoxic T-lymphocyte antigen (CTLA-4) on Treg during malaria and to evaluate their function. We found that P. vivax infection triggered an increase in circulating Treg and their expression of CTLA-4 and PD-1. Functional analysis demonstrated that Treg from malaria patients had impaired suppressive ability and PD-1+Treg displayed lower levels of Foxp3 and Helios, but had higher frequencies of T-box transcription factor+ and interferon-gamma+ cells than PD-1-Treg. Thus malaria infection alters the function of circulating Treg by triggering increased expression of PD-1 on Treg that is associated with decreased regulatory function and increased proinflammatory characteristics. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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