[The acquisition in dogs of temporal regulation by differentiated reinforcement of the response duration using an exteroceptive component and the pharmacological modulation of this reflex (diazepam, clozapine)].

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  • Author(s): Bruviller J;Bruviller J; Chleid E; Guer H; Mersier M
  • Source:
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 1992 Jan-Feb; Vol. 42 (1), pp. 61-74.
  • Publication Type:
    Journal Article
  • Language:
    Russian
  • Additional Information
    • Transliterated Title:
      Vyrabotka u sobak vremennóĭ reguliatsii putem differentsirovannogo podkrepleniia dlitel'nosti otveta s ispol'zovaniem éksterotseptivnogo komponenta i farmakologicheskaia moduliatsiia étogo refleksa (diazepam, klozepin).
    • Source:
      Publisher: Izd-Vo Akademiia Nauk Ssr Country of Publication: Russia (Federation) NLM ID: 9421551 Publication Model: Print Cited Medium: Print ISSN: 0044-4677 (Print) Linking ISSN: 00444677 NLM ISO Abbreviation: Zh Vyssh Nerv Deiat Im I P Pavlova Subsets: MEDLINE
    • Publication Information:
      Publication: Moscow : Izd-Vo Akademiia Nauk Ssr
      Original Publication: Moscow, Izd-vo Akademiia nauk SSR.
    • Subject Terms:
      Reinforcement, Psychology*; Clozapine/*pharmacology ; Conditioning, Classical/*physiology ; Diazepam/*pharmacology ; Proprioception/*physiology ; Reaction Time/*physiology ; Time Perception/*physiology; Animals ; Conditioning, Classical/drug effects ; Dogs ; Dose-Response Relationship, Drug ; Inhibition, Psychological ; Male ; Proprioception/drug effects ; Reaction Time/drug effects ; Time Factors ; Time Perception/drug effects
    • Abstract:
      Transformation of expectation phenomenon into the phenomenon of temporal regulation is usually achieved by the suppression of preliminary factors or by means of their physical modification. Our studies show that such transformation can be obtained in dogs using Kupalov paradigm with the presentation of additional stimuli. These stimuli strictly identical, from the physical point of view, to the signals which interrupt expectation are randomly introduced into the temporal limit. Absence of the reinforcement in response to the additional stimulus impels the animal to include temporal regulation in its behaviour, and an additional negative discriminative stimulus promotes an expression of active character of inhibition. These circumstances make our pattern closer to DRRD (differential reinforcement of response duration). In order to evaluate the merits of this procedure the influence was studied of anxiolytic (diazepam) and neuroleptic (closepine) on the stabilized reaction of experimental animals. The increase of responses duration by closepine and their shortening by diazepam as well as the influence of these pharmacological substances on the frequency of responses in dependence of dose, confirm the results of the previous studies of DRRD and DRL (differential reinforcement of low rate of responses) and prove differential sensitivity of our procedure to pharmacological substances.
    • Accession Number:
      J60AR2IKIC (Clozapine)
      Q3JTX2Q7TU (Diazepam)
    • Publication Date:
      Date Created: 19920101 Date Completed: 19920610 Latest Revision: 20191210
    • Publication Date:
      20221208
    • Accession Number:
      1316018