Superoxide dismutase in pediatric palatine tonsils and adenoids and its related clinical parameters.

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  • Additional Information
    • Source:
      Publisher: Saunders Country of Publication: United States NLM ID: 8000029 Publication Model: Print Cited Medium: Print ISSN: 0196-0709 (Print) Linking ISSN: 01960709 NLM ISO Abbreviation: Am J Otolaryngol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cherry Hill, N. J., Saunders.
    • Subject Terms:
      Adenoids/*metabolism ; Otitis Media with Effusion/*metabolism ; Palatine Tonsil/*metabolism ; Sinusitis/*metabolism ; Superoxide Dismutase/*biosynthesis ; Tonsillitis/*metabolism; Adenoids/chemistry ; Child ; Child, Preschool ; Female ; Humans ; Male ; Otitis Media with Effusion/complications ; Palatine Tonsil/chemistry ; Prospective Studies ; Sinusitis/complications ; Superoxide Dismutase/analysis ; Tonsillitis/complications
    • Abstract:
      Purpose: The objective of this study was to investigate a protective system of pediatric palatine tonsils and adenoids against superoxide radicals (O(2)(-)) and to evaluate the clinical factors including otitis media with effusion that are related to both the expression and activities of copper zinc superoxide dismutases (CuZnSODs).
      Design: CuZnSODs in the palatine tonsils and adenoids were studied using immunohistochemistry and reverse-transcription polymerase chain reaction.
      Results: Immunohistochemistry showed that CuZnSODs distribute in the crypt epithelium, mucous membrane, mantle zone, and extrafollicular area of the pediatric adenoids as well as in the palatine tonsils. Otitis media with effusion and paranasal sinusitis were related to CuZnSODs expression in the pediatric adenoids. In addition, the frequency of tonsillitis and presence of recent tonsillitis were significantly related to CuZnSODs expression in the pediatric tonsils (P <.05).
      Conclusions: In both the pediatric palatine tonsils and adenoids, the mechanism of tissue protection against infection and frequent inflammatory reactions may be closely related to CuZnSODs expression. There may be close relationship between the increased level of O(2)(-) that leads to an increase in CuZnSODs in the pediatric adenoid tissue and the development of otitis media.
    • Accession Number:
      EC 1.15.1.1 (Superoxide Dismutase)
    • Publication Date:
      Date Created: 20030918 Date Completed: 20040504 Latest Revision: 20190916
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/s0196-0709(03)00063-2
    • Accession Number:
      13130445