阿夫唑嗪联合盐酸莫西沙星治疗慢性前列腺炎的疗效及对血清TNF-琢、 IL-1茁、PSP、M-CSF水平的影响 (Chinese)

Efficacy of Alfuzosin Combined with Moxifloxacin Hydrochloride in Treatment of Chronic Prostatitis and Effect on SerumTNF-琢, IL-1茁, PSP and M-CSF Levels. (English)

Objective: To research the efficacy of alfuzosin combined with moxifloxacin hydrochloride in the treatment of chronic prostatitis and effect on the serum tumor necrosis factor-a(TNF-α), interleukin-1 β (IL-1β), pancreatic stone protein (PSP), macrophage colony stimulating factor (M-CSF) levels. Methods: 98 cases of patients with chronic prostatitis admitted from December 2014 to December 2016 were selected and divided into the control and the research group according to different treatment methods. The control group was treated with moxifloxacin hydrochloride, and the research group was treated with alfuzosin based on the control group. The curative effect, changes of serum TNF-α, IL-1β, PSP, M-CSF levels, chronic prostate inflammatory index score (NIH-CPSI) before and after treatment and incidence of adverse reactions were compared between two groups. Results: After treatment, the total effective rate of research group was 95.91%, which was significantly higher than that of the control group (77.55%, P<0.05). The serum TNF-α, IL-1β, PSP, M-CSF levels and NIH-CPSI scores of two group were all significantly lower than those before treatment, which were obviously lower in the research group than those of the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Alfuzosin combined with moxifloxacin hydrochloride was more effective in the treatment of chronic prostatitis than moxifloxacin alone, which might be related to reduce the serum TNF-α, IL-1β, PSP, M-CSF levels. [ABSTRACT FROM AUTHOR]

目的：探讨阿夫唑嗪联合盐酸莫西沙星治疗慢性前列腺炎的疗效及对血清肿瘤坏死因子-琢(TNF-琢)、白细胞介素-1茁 (IL-1茁)、胰石蛋白(PSP)、巨噬细胞集落刺激因子(M-CSF)水平的影响。方法：选择2014 年12 月~2016 年12 月于我院就诊的98 例 慢性前列腺炎患者，按不同治疗方式分为对组与研究组，每组49 例。对照组接受盐酸莫西沙星治疗，研究组基于对照组加以阿夫 唑嗪治疗。观察并比较两组的临床疗效，治疗前后血清TNF-琢、IL-1茁、PSP、M-CSF 水平、慢性前列腺炎症状指数评分(NIH-CPSI) 的变化及不良反应的发生情况。结果：治疗后，研究组总有效率为95.91%，显著高于对照组(77.55%，P<0.05)。两组治疗后血清 TNF-琢、IL-1茁、PSP、M-CSF 水平、NIH-CPSI评分均较治疗前显著下降，且研究组上述指标均明显低于对照组(P<0.05)。两组不良反 应的发生率比较差异无统计学意义(P>0.05)。结论：阿夫唑嗪联合盐酸莫西沙星治疗慢性前列腺炎的疗效优于单用盐酸莫西沙 星，可能与其显著降低血清TNF-琢、IL-1茁、PSP、M-CSF水平有关。 [ABSTRACT FROM AUTHOR]

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