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Edgar Allan Poe/Sullivan's Island Library
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West Ashley Library
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Wando Mount Pleasant Library
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Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
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Hurd/St. Andrews Library
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Increased antibiotic resistance exhibited by the biofilm of Vibrio cholerae O139.
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- Author(s): Gupta, Preeti; Mankere, Bharti; Keloth, Shami Chekkoora; Tuteja, Urmil; Pandey, Pratibha; Chelvam, Kulanthaivel Thava; Chekkoora Keloth, Shami
- Source:
Journal of Antimicrobial Chemotherapy (JAC); Jul2018, Vol. 73 Issue 7, p1841-1847, 7p- Subject Terms:
PATHOGENIC microorganisms; DRUG resistance in bacteria; MICROBIAL virulence; GRAM-negative bacteria; VIBRIO cholerae; ANIMAL experimentation; ANTIBIOTICS; BIOFILMS; CHOLERA; COMPARATIVE studies; DIARRHEA; DRUG resistance in microorganisms; EPIDEMICS; RESEARCH methodology; MEDICAL cooperation; MICE; MICROBIAL sensitivity tests; RESEARCH; EVALUATION research; PHARMACODYNAMICS - Source:
- Additional Information
- Subject Terms:
- Abstract:
Background: Vibrio cholerae, the aetiological agent of the deadly diarrhoeal disease cholera, is known to form biofilm. The antibiotic susceptibility status of biofilm of V. cholerae O139, an important epidemic strain in India and other countries, has not previously been studied in detail.Methods: Antibiotic susceptibility status of planktonic and biofilm cultures of V. cholerae O139 was evaluated by determining MIC, MBC and minimum biofilm eradication concentration (MBEC) values of five different classes of antibiotics using established methods. Effects of antibiotic treatment on planktonic and biofilm cultures were analysed by scanning electron microscopy. The virulence of the antibiotic-surviving population (ASP) was evaluated using an infant mouse model. The frequency of spontaneous mutants and inheritability of antibiotic resistance were determined with standard methods.Results: The antibiotic resistance exhibited by biofilm of V. cholerae O139 was found to be significantly higher (P < 0.05) than its planktonic counterpart. The biofilm-associated antibiotic resistance was found to be transient and exclusive to the biofilm culture. The frequency of ASP clones among antibiotic-treated biofilm cultures occurred at a rate of 0.012%-0.95% and these clones were found to retain the virulence and antibiotic resistance of their parent strains.Conclusions: The biofilm of V. cholerae O139 was found to be resistant to different types of antibiotics tested. This unconventional biofilm resistance highlights the hidden danger of antimicrobial escape by V. cholerae, increased risk of cholera transmission and its continued persistence in the environment. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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