英夫利昔单抗联合组胺受体拮抗剂治疗老年类风湿关节炎 疗效观察. (Chinese)

Objective To investigate the effect of infliximab combined histamine receptor antagonist therapy on the treatment of elderly patients with rheumatoid arthritis（RA），as well as the adverse effects.Methods A total of 60 cases RA patients admitted to this hospital were randomly divided into control group（27 cases）and observation group（33 cases）From July 2012 to June 2015..The control group received infliximab treatment（0.4 mg/kg，1every 2 weeks）.In the observation group received equal dosage of infliximab，in addition to oral administration of cetirizine hydrochloride tablets（25 mg/d）.The treatment duration was 12 weeks.The levels of rheumatoid factor（RF），C⁃reactive protein（CRP），interleukin⁃6（IL⁃6），IL⁃10 and CRP were measured before and after treatment. Results The number of joint swelling and pressure pain after treatment in the two groups were obviously improved，and the level of peripheral blood inflammatory cytokines was significantly lower than before the treatment（P<0.05）.The level of IL⁃6，CRP and the incidence of adverse drug reactions in the peripheral blood of the observation group were significantly lower than those of the control group，and the level of IL⁃10 was obviously lower than that of the control group.Significantly higher than the control group，the difference was statistically significant（P<0.05）. Conclusion Infliximab combined with histamine receptor antagonist can improve the symptoms of senile rheumatoid arthritis，improve the balance of inflammatory cytokines and antiinflammatory cytokines in peripheral blood，and reduce the incidence of adverse reactions. [ABSTRACT FROM AUTHOR]

目的研究英夫利昔单抗联合组胺受体拮抗剂治疗老年类风湿关节炎（RA）的疗效及对不良反应的影 响。方法选取2012 年7 月至2015 年6 月该院收治的老年RA 患者60 例，采用患者病历编号随机分为对照组（27 例）和观察组（33 例）。对照组接受英夫利昔单抗治疗（0.4 mg/kg，每2 周1 次），观察组在接受同等剂量英夫利昔单抗治 疗同时口服盐酸西替利嗪片（25 mg/d），持续治疗12 周。记录两组患者治疗前后关节肿胀、压痛、疾病活动评 ，以及外 周血类风湿因子、外周血炎性细胞因子[白细胞介素⁃6（IL⁃6）、IL⁃10]及C 反应蛋白水平（CRP）等，进行疗效比较。结果 两组患者治疗后关节肿胀、压痛数量均明显改善，外周血炎性细胞因子水平均较治疗前明显降低，差异均有统计学意义 （P<0.05）；观察组患者治疗后外周血IL⁃6、CRP 水平及不良反应发生率均明显低于对照组，IL⁃10 水平明显高于对照组，差异均有统计学意义（P<0.05）。结论英夫利昔单抗联合组胺受体拮抗剂治疗可明显改善老年RA 患者症状，改善外 周血促炎性细胞因子和抗炎性细胞因子平衡，降低不良反应发生率。 [ABSTRACT FROM AUTHOR]

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