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Association between polymorphisms of DNA repair genes and risk of type 2 diabetes mellitus in the Turkish population.
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- Author(s): Tokmak, Neslihan; Yilmaz, Umit; Yilmaz, Nesibe; Yurdum, Leman Melis; Yigitbasi, Nihal; Ergen, Hayriye Arzu; Karaali, Zeynep; Zeybek, Sakir Umit
- Source:
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi; Apr2018, Vol. 43 Issue 2, p167-172, 6p- Subject Terms:
- Source:
- Additional Information
- Abstract: Objectives: DNA repair mechanisms work insufficiently in T2DM patients and hyperglycemia seen in diabetes disturbs the oxidant-antioxidant balance thus cause oxidative damage on DNA. The effects of the DNA repair genes’ have not yet been investigated on diabetes. The aim of this study was to investigate the association between
APE1 Asp148Glu andXPG Asp1104His polymorphisms with T2DM in the Turkish population. Material and methods: Sixty-five T2DM patients and 54 healthy individuals were included to this study as control. The polymerase chain reaction-restriction fragment length polymorphism techniques were used. Results: When the study groups were compared, serum HDL-cholesterol levels were found statistically elevated in the controls. Once theAPE1 Asp148Glu polymorphism distribution between the patient and control groups was investigated, the Glu/Glu genotype ratio was found significantly higher in the control group. Furthermore, the Asp/Glu genotype and the Asp allele prevalences were observed to be higher in the patient group. Also, patients with the Asp/Asp genotype had higher serum HDL-cholesterol levels than the others. Conclusion: Despite the small number of subjects included, it could be interpreted that the Glu allele of theAPE1 Asp148Glu polymorphism might be protective against and the Asp allele may be contributing to the development of diabetes. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Turkish Journal of Biochemistry / Turk Biyokimya Dergisi is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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