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Regulation of arachidonic acid availability for eicosanoid production.
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- Abstract:
Mammalian cells have developed specific pathways for the incorporation, remodeling, and release of arachidonic acid. Acyltransferase and transacylase pathways function to regulate the levels of esterified arachidonic acid in specific phospholipid pools. There are several distinct, differentially regulated phospholipases A2 in cells that mediate agonist-induced release of arachidonic acid. These pathways are important in controlling cellular levels of free arachidonic acid. Both arachidonic acid and its oxygenated metabolites are potent bioactive mediators that regulate a myriad of physiological and pathophysiological processes. [ABSTRACT FROM AUTHOR]
- Abstract:
Les cellules de mammifères ont acquis des voies spécifiques pour l'incorporation, la redistribution et la libération de l'acide arachidonique. Les voies de l'acyltransférase et de la transacylase servent à régler le taux d'acide arachidonique estérifié dans des pools spécifiques de phospholipides. Il y a plusieurs phospholipases A2, distinctes et réglées différemment, dans les cellules où il y a une libération d'acide arachidonique induite par un agoniste. Ces voies sont importantes pour la régulation de la concentration de l'acide arachidonique non estérifiée dans les cellules. L'acide arachidonique et ses métabolites oxygénés sont de puissants médiateurs bioactifs qui règlent une multitude de processus physiologiques et physiopathologiques. [ABSTRACT FROM AUTHOR]
- Abstract:
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