Sex difference in the effect of obesity on 24-hour mean serum gonadotropin levels.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Strain GW;Strain GW; Zumoff B; Miller LK; Rosner W
  • Source:
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme [Horm Metab Res] 2003 Jun; Vol. 35 (6), pp. 362-6.
  • Publication Type:
    Comparative Study; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Thieme Country of Publication: Germany NLM ID: 0177722 Publication Model: Print Cited Medium: Print ISSN: 0018-5043 (Print) Linking ISSN: 00185043 NLM ISO Abbreviation: Horm Metab Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Stuttgart, Thieme.
    • Subject Terms:
      Circadian Rhythm* ; Sex Characteristics*; Follicle Stimulating Hormone/*blood ; Luteinizing Hormone/*blood ; Obesity/*blood; Animals ; Body Mass Index ; Estradiol/blood ; Female ; Testosterone/blood
    • Abstract:
      To determine the effect of obesity on serum gonadotropin levels and any possible sex difference in the effect, we measured the 24-hour mean serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) concentrations in 62 healthy men with Body Mass Index (BMI) ranging from 20 - 94 and 61 healthy, regularly cycling women with BMIs ranging from 19 - 76. We also measured free testosterone (T) and estradiol (E2) in these subjects. There was a significant negative correlation between serum FSH and BMI in men: FSH(IU/L) = 49.9 x BMI -0.567; r = - 0.376, p = 0.0026; but a significant positive correlation between serum FSH and BMI in women: FSH(IU/L) =7.66 +/- 0.071 x BMI; r = 0.302, p = 0.018. Serum LH was weight-invariant in both sexes. In men, free T was negatively correlated with BMI: Free T (nmol/L) = 0.74 - 0.0068 x BMI; r = 0.585, p = 0.0381; and free E2 was positively correlated with BMI: Free E2 (pmol/L) = - 1.03 +/- 0.057 x BMI; r = 0.50, p = 0.0014. In obese women as a group, free T was higher than in lean women (33 +/- 6.8 S.E.M. vs. 17.4 +/- 2.0 pmol/L; p < 0.0001), and free E2 was also higher than in lean women: (6.90 +/- 0.80 vs. 4.84 +/- 0.55 pmol/L; p = 0.046). Of the many cases of hypothalamic-pituitary hormonal dysregulation that have been reported in obesity, none has been studied for sex differences. Our results mandate that possible sex differences be investigated in all cases of dysregulation.
    • Accession Number:
      3XMK78S47O (Testosterone)
      4TI98Z838E (Estradiol)
      9002-67-9 (Luteinizing Hormone)
      9002-68-0 (Follicle Stimulating Hormone)
    • Publication Date:
      Date Created: 20030816 Date Completed: 20040521 Latest Revision: 20131121
    • Publication Date:
      20240627
    • Accession Number:
      10.1055/s-2003-41358
    • Accession Number:
      12920659