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Growth, invasion, metastasis, differentiation, angiogenesis and apoptosis of gastric cancer regulated by expression of PTEN encoding products.
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- Author(s): Zheng HC;Zheng HC; Li YL; Sun JM; Yang XF; Li XH; Jiang WG; Zhang YC; Xin Y
- Source:
World journal of gastroenterology [World J Gastroenterol] 2003 Aug; Vol. 9 (8), pp. 1662-6.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Print ISSN: 1007-9327 (Print) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE
- Publication Information: Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group
Original Publication: Beijing : WJG Press, c1998- - Subject Terms: Apoptosis* ; Neovascularization, Pathologic*; Phosphoric Monoester Hydrolases/*genetics ; Stomach Neoplasms/*blood supply ; Stomach Neoplasms/*pathology ; Tumor Suppressor Proteins/*genetics; Adult ; Aged ; Aged, 80 and over ; Caspase 3 ; Caspases/metabolism ; Cell Differentiation ; Female ; Gastric Mucosa/metabolism ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; PTEN Phosphohydrolase ; Phosphoric Monoester Hydrolases/metabolism ; Stomach Neoplasms/physiopathology ; Stomach Neoplasms/secondary ; Tumor Suppressor Proteins/metabolism
- Abstract: Aim: To investigate expression of PTEN in gastric cancer and to explore its roles in tumorigenesis and progression of gastric cancer.
Methods: Formalin-fixed and paraffin-embedded tissues of adjacent non-tumor mucosa and primary foci from 113 cases of gastric cancers were studied for the expression of PTEN and Caspase-3 and microvessel density (MVD) by streptavidin-peroxidase (S-P) immunohistochemistry with antibodies against PTEN, Caspase-3, and CD34. The relationship between PTEN and Caspase 3 expression and clinicopathological parameters of tumors was compared.
Results: Primary gastric cancer cells expressed PTEN less frequently than adjacent epithelial cells of primary foci (54.9 % vs 89.4 %; P=0.000, chi(2)=33.474). PTEN expression was significantly associated with invasive depth (P=0.003, rs=0.274), metastasis (P=0.036, rs=0.197), growth pattern (P=0.008, rs=0.282), Lauren's classification (P=0.000, rs=0.345), and histological classification (P=0.005, rs=0.262) of tumors, but not with tumor size (P=0.639, rs=0.045), Borrmann's classification (P=0.544, rs=0.070) or TNM staging (P=0.172, rs=0.129). PTEN expression was negatively correlated with MDV in primary gastric cancer (P=0.020, F=5.558). Primary gastric cancer cells showed less frequent immunoreactivity to Caspase-3 than adjacent epithelial cells of primary foci (32.7 % vs 50.4 %; P=0.007, chi(2)=7.286). Caspase-3 expression was dependent of PTEN expression in primary gastric cancer cells (P=0.000, chi(2)=15.266).
Conclusion: Down-regulated expression of PTEN plays an important role in tumorigenesis, progression, growth, differentiation and angiogenesis of gastric cancer. Low expression of PTEN can decrease expression of Caspase-3 to disorder apoptosis of tumor cells, which might explain the molecular mechanisms of PTEN contributions to tumorigenesis and progression of gastric cancer. - References: Annu Rev Biochem. 2001;70:247-79. (PMID: 11395408)
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EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
EC 3.1.3.67 (PTEN Phosphohydrolase)
EC 3.1.3.67 (PTEN protein, human)
EC 3.4.22.- (CASP3 protein, human)
EC 3.4.22.- (Caspase 3)
EC 3.4.22.- (Caspases) - Publication Date: Date Created: 20030815 Date Completed: 20030924 Latest Revision: 20220310
- Publication Date: 20221213
- Accession Number: PMC4611520
- Accession Number: 10.3748/wjg.v9.i8.1662
- Accession Number: 12918097
- Source:
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