Diagnostic value of analysis of cystatin C and protein HC in biological fluids.

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  • Author(s): Grubb A;Grubb A
  • Source:
    Clinical nephrology [Clin Nephrol] 1992; Vol. 38 Suppl 1, pp. S20-7.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Dustri-Verlag Dr. Karl Feistle Country of Publication: Germany NLM ID: 0364441 Publication Model: Print Cited Medium: Print ISSN: 0301-0430 (Print) Linking ISSN: 03010430 NLM ISO Abbreviation: Clin Nephrol Subsets: MEDLINE
    • Publication Information:
      Original Publication: München-Deisenhofen, Dustri-Verlag Dr. Karl Feistle.
    • Subject Terms:
      Alpha-Globulins/*analysis ; Cystatins/*analysis ; Cysteine Proteinase Inhibitors/*analysis ; Kidney Diseases/*diagnosis ; Protease Inhibitors/*analysis; Alpha-Globulins/chemistry ; Amino Acid Sequence ; Cystatin C ; Cystatins/chemistry ; Cysteine Proteinase Inhibitors/chemistry ; Glomerular Filtration Rate ; Humans ; Kidney Function Tests ; Leukemia, Myeloid/diagnosis ; Lymphoproliferative Disorders/diagnosis ; Molecular Sequence Data ; Protease Inhibitors/chemistry ; Reference Values
    • Abstract:
      Cystatin C, a 13 kDa-protein, is produced by most nucleated cells and is catabolized by the renal tubular cells after passing the glomerular filter. It belongs to the family 2 of the cystatin superfamily of proteins. The function of cystatin C is to regulate the activity of cysteine proteinases and cystatin C seems to be the main cysteine proteinase inhibitor of most investigated human biological fluids. Its normal level in plasma is 0.8-2.5 mg/l, in cerebrospinal fluid 4-14 mg/l and in urine 0.03-0.3 mg/l. The production rate of cystatin C is remarkably constant and its plasma concentration can therefore be used as a reliable measure of the glomerular filtration rate (GFR). Indeed, the cystatin C plasma concentration is more closely correlated to the GFR than the plasma levels of creatinine and all other investigated low molecular weight proteins, including beta 2-microglobulin and retinol binding protein. Protein HC, alias alpha 1-microglobulin, is produced by the liver as a 27 kDa-glycoprotein. It belongs to the lipocalin superfamily of hydrophobic ligand binding proteins and more than 50% of the normal plasma amount of protein HC is present as a high molecular weight HC-IgA complex carrying antibody activity. The plasma concentration of free protein HC is, in contrast to that of HC-IgA, mainly determined by the GFR. The normal values for the plasma concentrations of HC-IgA and free protein HC are 36-620 mg/l and 14-26 mg/l, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
    • Number of References:
      65
    • Accession Number:
      0 (Alpha-Globulins)
      0 (CST3 protein, human)
      0 (Cystatin C)
      0 (Cystatins)
      0 (Cysteine Proteinase Inhibitors)
      0 (Protease Inhibitors)
      0 (alpha-1-microglobulin)
    • Publication Date:
      Date Created: 19920101 Date Completed: 19930421 Latest Revision: 20220321
    • Publication Date:
      20240513
    • Accession Number:
      1284235