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Wando Mount Pleasant Library
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Long-term efficacy of standardised specific subcutaneous immunotherapy in children with persistent allergic rhinitis due to multiple allergens including house dust mites.
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- Author(s): Song, Y1; Long, J1; Wang, T1; Xie, J2; Wang, M2; Tan, G1
- Source:
Journal of Laryngology & Otology. Mar2018, Vol. 132 Issue 3, p230-235. 6p.- Subject Terms:
*ADRENOCORTICAL hormones; *HORMONE therapy; *RHINITIS treatment; *INTRANASAL medication; *ALLERGENS; *ALLERGY desensitization; *ANTIHISTAMINES; *IMMUNOTHERAPY; *MITES; *QUALITY of life; *QUESTIONNAIRES; *RHINITIS; *VISUAL analog scale; *TREATMENT effectiveness; *TREATMENT duration; *SUBCUTANEOUS infusions; *CHILDREN; *PSYCHOLOGY - Source:
- Additional Information
- Abstract: Objectives:To observe the five-year efficacy of standardised specific subcutaneous immunotherapy for house dust mite allergy in monosensitised and polysensitised children with persistent allergic rhinitis.Methods:From January 2007 to August 2009, 236 children with persistent allergic rhinitis were divided into 2 groups: 1 group received standardised specific subcutaneous immunotherapy using house dust mite extract; the other received pharmacotherapy with intranasal corticosteroids and oral antihistamines. A total of 193 patients (106 in the immunotherapy group and 87 in the pharmacotherapy group) completed treatment. Scores for symptoms, total medication and quality of life were evaluated.Results:The subcutaneous immunotherapy group demonstrated a significant reduction in visual analogue scale scores, Rhinoconjunctivitis Quality of Life Questionnaire scores and total medication scores (p < 0.05) compared with the pharmacotherapy group. No significant differences in the visual analogue scale and Rhinoconjunctivitis Quality of Life Questionnaire scores were found between the polysensitised and monosensitised subgroups (p > 0.05). No serious adverse events occurred.Conclusion:Standardised subcutaneous immunotherapy has long-term efficacy for children with persistent allergic rhinitis. Single-allergen subcutaneous immunotherapy was appropriate for allergic rhinitis caused by multiple allergens, including house dust mites, in the paediatric population. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Laryngology & Otology is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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