Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study.

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  • Additional Information
    • Corporate Authors:
      Atherosclerosis Risk in Communities Study
    • Source:
      Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Print ISSN: 0012-1797 (Print) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
    • Publication Information:
      Publication: Alexandria, VA : American Diabetes Association
      Original Publication: [New York, American Diabetes Association]
    • Subject Terms:
      Diabetes Mellitus, Type 2/*epidemiology ; Inflammation/*physiopathology; Black People ; Blood Glucose/metabolism ; Case-Control Studies ; Cohort Studies ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Reference Values ; Risk Factors ; Smoking ; United States/epidemiology ; White People ; Black or African American
    • Abstract:
      To examine the association of low-grade systemic inflammation with diabetes, as well as its heterogeneity across subgroups, we designed a case-cohort study representing the approximately 9-year experience of 10,275 Atherosclerosis Risk in Communities Study participants. Analytes were measured on stored plasma of 581 incident cases of diabetes and 572 noncases. Statistically significant hazard ratios of developing diabetes for those in the fourth (versus first) quartile of inflammation markers, adjusted for age, sex, ethnicity, study center, parental history of diabetes, and hypertension, ranged from 1.9 to 2.8 for sialic acid, orosomucoid, interleukin-6, and C-reactive protein. After additional adjustment for BMI, waist-to-hip ratio, and fasting glucose and insulin, only the interleukin-6 association remained statistically significant (HR = 1.6, 1.01-2.7). Exclusion of GAD antibody-positive individuals changed associations minimally. An overall inflammation score based on these four markers plus white cell count and fibrinogen predicted diabetes in whites but not African Americans (interaction P = 0.005) and in nonsmokers but not smokers (interaction P = 0.13). The fully adjusted hazard ratio comparing white nonsmokers with score extremes was 3.7 (P for linear trend = 0.008). In conclusion, a low-grade inflammation predicts incident type 2 diabetes. The association is absent in smokers and African-Americans.
    • Grant Information:
      5R01-DK56918-03 United States DK NIDDK NIH HHS; N01-HC-55015 United States HC NHLBI NIH HHS; N01-HC-55016 United States HC NHLBI NIH HHS; N01-HC-55018 United States HC NHLBI NIH HHS; N01-HC-55019 United States HC NHLBI NIH HHS; N01-HC-55020 United States HC NHLBI NIH HHS; N01-HC-55021 United States HC NHLBI NIH HHS; N01-HC-55022 United States HC NHLBI NIH HHS
    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20030628 Date Completed: 20030819 Latest Revision: 20240712
    • Publication Date:
      20240712
    • Accession Number:
      10.2337/diabetes.52.7.1799
    • Accession Number:
      12829649