Protection by L-fucose and fucose-rich polysaccharides against ROS-produced cell death in presence of ascorbate.

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  • Author(s): Péterszegi G;Péterszegi G; Robert AM; Robert L
  • Source:
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2003 May-Jun; Vol. 57 (3-4), pp. 130-3.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print Cited Medium: Print ISSN: 0753-3322 (Print) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
    • Publication Information:
      Publication: Paris : Editions Scientifiques Elsevier
      Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
    • Subject Terms:
      Antioxidants/*pharmacology ; Ascorbic Acid/*pharmacology ; Fucose/*pharmacology ; Polysaccharides/*pharmacology ; Reactive Oxygen Species/*antagonists & inhibitors ; Reactive Oxygen Species/*toxicity; Catalase/pharmacology ; Cell Adhesion/drug effects ; Cell Death/drug effects ; Fibroblasts/drug effects ; Fibroblasts/enzymology ; Fibronectins/biosynthesis ; Humans ; Skin/cytology ; Skin/enzymology ; Superoxide Dismutase/pharmacology
    • Abstract:
      It was shown previously, that millimolar concentrations of ascorbate have cytotoxic and anti-proliferative effects (Eur. J. Clin. Invest. 32 (2002) 372). With increasing concentrations of ascorbate an increasing number of fibroblasts was detached from the culture dish and shown to be lysed by the effect of ascorbate-induced generation of reactive oxygen species (ROS-s). It also could be shown, that this cytotoxic effect is partly due to the dose-dependent inhibition by ascorbate of fibronectin biosynthesis. Superoxide dismutase (SOD) and catalase were shown to salvage cells from ROS-induced cell-death by preventing the inhibition of fibronectin biosynthesis. We used this model system to test the cyto-protective effect of L-fucose and fucose-rich oligo- and polysaccharides (FROP-s). It appeared that relatively low concentrations of L-fucose and FROP-3 (Biomed. Pharmacother. in press) could efficiently protect fibroblasts from the ascorbate-induced cell-death. These novel pharmacological properties of L-fucose and FROP-3 might well be related to their accelerating effect of wound healing.
    • Accession Number:
      0 (Antioxidants)
      0 (Fibronectins)
      0 (Polysaccharides)
      0 (Reactive Oxygen Species)
      28RYY2IV3F (Fucose)
      EC 1.11.1.6 (Catalase)
      EC 1.15.1.1 (Superoxide Dismutase)
      PQ6CK8PD0R (Ascorbic Acid)
    • Publication Date:
      Date Created: 20030624 Date Completed: 20040210 Latest Revision: 20191025
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/s0753-3322(03)00019-2
    • Accession Number:
      12818474