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Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor.
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- Additional Information
- Source:
Publisher: Oxford University Press Country of Publication: England NLM ID: 2985192R Publication Model: Print Cited Medium: Print ISSN: 0022-3069 (Print) Linking ISSN: 00223069 NLM ISO Abbreviation: J Neuropathol Exp Neurol Subsets: MEDLINE
- Publication Information:
Publication: 2016- : Oxford, England : Oxford University Press
Original Publication: Lawrence, Ks : Association of the journal of neuropathology and experimental neurology
- Subject Terms:
Apoptosis/
*genetics ;
Nerve Growth Factor/
*metabolism ;
Peripheral Nervous System Diseases/
*metabolism ;
Receptors, Nerve Growth Factor/
*metabolism ;
Schwann Cells/
*metabolism ;
Sciatic Nerve/
*injuries ;
Sciatic Neuropathy/
*metabolism;
Animals ;
Animals, Newborn ;
Apoptosis/
drug effects ;
Axons/
metabolism ;
Axons/
pathology ;
Axons/
ultrastructure ;
Axotomy ;
Chemotaxis, Leukocyte/
drug effects ;
Chemotaxis, Leukocyte/
genetics ;
Immunohistochemistry ;
Mice ;
Mice, Inbred BALB C ;
Mice, Mutant Strains ;
Microscopy, Electron ;
Mutation/
genetics ;
Nerve Growth Factor/
antagonists & inhibitors ;
Peripheral Nervous System Diseases/
genetics ;
Peripheral Nervous System Diseases/
physiopathology ;
Receptor, Nerve Growth Factor ;
Receptors, Nerve Growth Factor/
drug effects ;
Receptors, Nerve Growth Factor/
genetics ;
S100 Proteins/
metabolism ;
Schwann Cells/
pathology ;
Schwann Cells/
ultrastructure ;
Sciatic Nerve/
growth & development ;
Sciatic Nerve/
metabolism ;
Sciatic Neuropathy/
genetics ;
Sciatic Neuropathy/
physiopathology ;
Signal Transduction/
genetics - Abstract:
Schwann cell death is a developmentally regulated phenomenon and is also induced after peripheral nerve axotomy in neonatal rodents. In this study, we explored whether ligand-induced activation of the low-affinity neurotrophin receptor (p75(NTR)) is responsible for inducing Schwann cell death in vivo. Administration of exogenous nerve growth factor (NGF) to the axotomized nerve site in wild-type animals resulted in a 2.6-fold increase in Schwann cell apoptosis in the distal nerve stumps compared to axotomy alone. No increase in apoptosis, above baseline levels, was seen in p75(NTR)-mutant mice either with or without NGF When anti-NGF antibodies were administered to the site of the peripheral nerve lesion in wild-type mice there was a reduction in the percentage of Schwann cell apoptosis to levels seen in both the quiescent state and in the axotomized nerves of the p75(NTR)-mutant mice. These results demonstrate that apoptosis of Schwann cells in axotomized peripheral nerve is mediated predominantly through p75(NTR) signaling and initiated via endogenously produced NGF.
- Accession Number:
0 (Receptor, Nerve Growth Factor)
0 (Receptors, Nerve Growth Factor)
0 (S100 Proteins)
9061-61-4 (Nerve Growth Factor)
- Publication Date:
Date Created: 20030502 Date Completed: 20030521 Latest Revision: 20190513
- Publication Date:
20240829
- Accession Number:
10.1093/jnen/62.4.398
- Accession Number:
12722832
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