Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs.

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    • Subject Terms:
      ANTIBACTERIAL agents; ANTIOXIDANTS; HERBS; ZINC content of plants; ETHANOL; PHENOLS; SOLVENTS
    • Abstract:
      Context:Crataegus monogynaL. (Rosaceae) (CM),Equisetum telmateiaL. (Equisataceae) (ET),Geranium purpureumVil. (Geraniaceae) (GP),Mentha suaveolensEhrh. (Lamiaceae) (MS), andLavandula stoechasL. spp. luisieri (Lamiaceae) (LS) are all medicinal. Objective:To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. Material and methods:Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW). Antioxidant activity was measured with TAA, FRAP and RP methods. Phenolics were quantified with a HPLC. Zinc was quantified using voltammetry. Antibacterial activity (after 48 h) was tested usingEnterococcus faecalis,Bacillus cereus,Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosaandListeria monocytogenes.Antiproliferative activity (after 24 h) was tested using HEP G2 cells and fibroblasts. Results:Solvents influenced results; the best were E and 80EW. GP had the highest antioxidant activity (TAA and FRAP of 536.90 mg AAE/g dw and 783.48 mg TE/g dw, respectively). CM had the highest zinc concentration (37.21 mg/kg) and phenolic variety, with neochlorogenic acid as the most abundant (92.91 mg/100 g dw). LS was rich in rosmarinic acid (301.71 mg/100 g dw). GP and LS inhibited the most microorganisms:B. cereus, E. coliandS. aureus. GP also inhibitedE. faecalis.CM had the lowest MIC: 5830 μg/mL. The antibacterial activity is explained by the phenolics present. LS and CM showed the most significant anti-proliferative activity, which is explained by their zinc content. Conclusion:The most promising plants for further studies are CM, LS and GP. [ABSTRACT FROM AUTHOR]
    • Abstract:
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