[Immunohistochemical findings in prolonged cerebral hypoxia].

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  • Author(s): Bouska I;Bouska I; Klír P
  • Source:
    Soudni lekarstvi [Soud Lek] 2003 Jan; Vol. 48 (1), pp. 2-4.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Czech
  • Additional Information
    • Transliterated Title:
      Imunohistochemické nálezy pri protrahované mozkové hypoxii.
    • Source:
      Publisher: Státní zdravotnické nakladatelstvi Country of Publication: Czech Republic NLM ID: 9601665 Publication Model: Print Cited Medium: Print ISSN: 0371-1854 (Print) Linking ISSN: 03711854 NLM ISO Abbreviation: Soud Lek Subsets: MEDLINE
    • Publication Information:
      Original Publication: Praha : Státní zdravotnické nakladatelství,
    • Subject Terms:
      Hypoxia, Brain/*metabolism ; Matrix Metalloproteinase 2/*analysis ; Matrix Metalloproteinase 9/*analysis; Adolescent ; Adult ; Brain Chemistry ; Cerebral Arteries/chemistry ; Child ; Child, Preschool ; Female ; Humans ; Hypoxia, Brain/pathology ; Immunohistochemistry ; Infant ; Male ; Middle Aged
    • Abstract:
      In the development of secondary changes of brain damage caused by injury, tumour and hypoxia of different origin with unconsciousness also the activity of the metalloproteinase matrix (MMP) may participate. Their activation occurs first in the vascular wall which they damage and it may be assumed that MMP potentiate thus secondary changes in the sense of interfering with the haematoencephalic barrier with development of vasogenic cerebral oedema. In the cells of the vascular wall and in glial elements already after two days MMP-2 and MMP-9 activity was proved. While in focal injuries the findings were in particular at the site of contusion foci, in prolonged hypoxia for various reasons these changes were diffuse.
    • Accession Number:
      EC 3.4.24.24 (Matrix Metalloproteinase 2)
      EC 3.4.24.35 (Matrix Metalloproteinase 9)
    • Publication Date:
      Date Created: 20030404 Date Completed: 20030424 Latest Revision: 20161021
    • Publication Date:
      20240829
    • Accession Number:
      12673944