Antiinflamatoarele nesteroidiene - tratament de primă linie pentru durerile musculare şi articulare. (Romanian)

Nonsteroidal anti-inflammatory drugs - first-line treatment in muscle and joint pain. (English)

There are many types of pain, classified according to its duration, mechanism of action and the site of pain, with direct impact on treatment strategy. This article adresses the therapeutic features of musculoskeletal pain. The systemic administration of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) is efficient, but limited by their hepatic and gastrointestinal, cardiovascular and renal adverse reactions, respectively. NSAIDs can be applied topically, as oinment, gel or spray, being just as effective as oral administration in hand and knee osteoarthritis. Their safety is superior to the systemic administration of NSAIDs, too. Currently, several osteoarthritis pain manangement guidelines recommend the use of topically aplied NSAIDs as first-line therapy. [ABSTRACT FROM AUTHOR]

Există mai multe tipuri de durere, clasificate în funcţie de durata, mecanismul de apariţie sau de localizarea acesteia, cu implicaţii directe asupra schemelor de tratament. Acest articol abordează particularităţile teraputice ale durerii musculoscheletale. Utilizarea paracetamolului şi a antiinflamatoarelor nesteroidiene (AINS) administrate sistemic este eficientă, dar grevată de efecte adverse hepatice, respectiv gastrointestinale, cardiovasculare şi renale. AINS pot fi administrate şi topic, sub formă de cremă, gel sau spray, cu eficacitate similară administrării orale în cazul osteoartritei mâinii şi genunchiului şi cu un profil de siguranţă superior administrării sistemice. În prezent, mai multe ghiduri de management al durerii din cadrul osteoartritei recomandă utilizarea ca primă linie terapeutică a AINS topice. [ABSTRACT FROM AUTHOR]

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