[NSAIDs caused gastric mucosal injury: with a special reference to COX-2].

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  • Author(s): Sakamoto C;Sakamoto C
  • Source:
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi [J Nippon Med Sch] 2003 Feb; Vol. 70 (1), pp. 5-11.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Medical Association of Nippon Medical School Country of Publication: Japan NLM ID: 100935589 Publication Model: Print Cited Medium: Print ISSN: 1345-4676 (Print) Linking ISSN: 13454676 NLM ISO Abbreviation: J Nippon Med Sch Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tokyo : Medical Association of Nippon Medical School, 2000-
    • Subject Terms:
      Anti-Inflammatory Agents, Non-Steroidal/*adverse effects ; Cyclooxygenase Inhibitors/*therapeutic use ; Gastric Mucosa/*drug effects ; Isoenzymes/*physiology ; Prostaglandin-Endoperoxide Synthases/*physiology; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Humans ; Isoenzymes/metabolism ; Membrane Proteins ; Prostaglandin-Endoperoxide Synthases/metabolism
    • Abstract:
      Nonsteroidal antiinflammatory drugs (NSAIDs) have been shown to cause mucosal injury in the gastrointestinal tract as a side effect, occasionally turning out to be severe complications such as bleeding and perforation. So far NSAIDs-caused mucosal injury was attributed to their inhibitory effects on the activity of cyclooxygenase-1 (COX-1) which is expressed and shown to play a crucial role for the mucosal protection via producing prostaglandin E2 in the stomach. However, a recent progress of the understanding about COX physiology has revealed that NSAIDs cause gastric mucosal injury by inhibiting not only COX-1 but also COX-2 in the stomach. COX-1 inhibition alone has been demonstrated not to cause gastric mucosal injury. In addition, a selective COX-2 inhibitor which is demonstrated to have much less harmful effect in the stomach is now widely used as a safer NSAID in USA. Moreover, a selective COX-2 inhibitor is recently considered to have an inhibitory effect on growth of a certain type of cancers, thereby being in the spotlight as a chemopreventive agent.
    • Number of References:
      18
    • Accession Number:
      0 (Anti-Inflammatory Agents, Non-Steroidal)
      0 (Cyclooxygenase 2 Inhibitors)
      0 (Cyclooxygenase Inhibitors)
      0 (Isoenzymes)
      0 (Membrane Proteins)
      EC 1.14.99.1 (Cyclooxygenase 2)
      EC 1.14.99.1 (PTGS2 protein, human)
      EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
    • Publication Date:
      Date Created: 20030321 Date Completed: 20030507 Latest Revision: 20191025
    • Publication Date:
      20231215
    • Accession Number:
      10.1272/jnms.70.5
    • Accession Number:
      12646969