Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Print ISSN: 0006-4971 (Print) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
    • Publication Information:
      Publication: 2021- : [New York] : Elsevier
      Original Publication: New York, Grune & Stratton [etc.]
    • Subject Terms:
      Histiocytosis, Langerhans-Cell/*metabolism ; Langerhans Cells/*pathology ; Receptors, Chemokine/*biosynthesis; Chemokine CCL20 ; Chemokines, CC/analysis ; Chemokines, CC/physiology ; Chemotaxis ; Histiocytosis, Langerhans-Cell/pathology ; Humans ; Immunohistochemistry ; Keratinocytes/chemistry ; Langerhans Cells/chemistry ; Macrophage Inflammatory Proteins/analysis ; Macrophage Inflammatory Proteins/physiology ; Macrophages/chemistry ; Osteoblasts/chemistry ; Receptors, CCR6 ; Receptors, CCR7 ; Receptors, Chemokine/physiology
    • Abstract:
      It has been suggested that a switch in chemokine receptor expression underlies Langerhans cell migration from skin to lymphoid tissue. Activated cells are thought to down-regulate CCR6, whose ligand macrophage inflammatory protein-3 alpha (MIP-3 alpha)/CCL20 is expressed in skin, and up-regulate CCR7, whose ligands are in lymphoid tissues. In Langerhans cell histiocytosis (LCH), pathologic Langerhans cells (LCs) accumulate in several tissues, including skin, bone, and lymphoid organs. We have examined 24 LCH cases and find that pathologic LCs expressed CCR6 and CCR7 coincidentally in all cases. Furthermore, MIP-3 alpha/CCL20 is expressed by keratinocytes in involved skin and by macrophages and osteoblasts in involved bone. Expression of CCR6 by pathologic LCs may contribute to their accumulation in nonlymphoid organs such as skin and bone, whereas CCR7 expression may direct them to lymphoid tissue. Histiocytes in Rosai-Dorfman disease and hemophagocytic syndrome also coexpressed CCR6 and CCR7, suggesting that this may be a general attribute of abnormal histiocytes.
    • Comments:
      Erratum in: Blood. 2003 Nov 15;102(10):3477.
    • Grant Information:
      AI50225 United States AI NIAID NIH HHS; CA53091 United States CA NCI NIH HHS
    • Accession Number:
      0 (CCL20 protein, human)
      0 (CCR6 protein, human)
      0 (CCR7 protein, human)
      0 (Chemokine CCL20)
      0 (Chemokines, CC)
      0 (Macrophage Inflammatory Proteins)
      0 (Receptors, CCR6)
      0 (Receptors, CCR7)
      0 (Receptors, Chemokine)
    • Publication Date:
      Date Created: 20030319 Date Completed: 20030521 Latest Revision: 20210206
    • Publication Date:
      20231215
    • Accession Number:
      10.1182/blood.V101.7.2473
    • Accession Number:
      12642342