Optic neuropathy in cancer patients. Report of a case possibly related to 5 fluorouracil toxicity and review of the literature.

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  • Author(s): Delval L;Delval L; Klastersky J
  • Source:
    Journal of neuro-oncology [J Neurooncol] 2002 Nov; Vol. 60 (2), pp. 165-9.
  • Publication Type:
    Case Reports; Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Print Cited Medium: Print ISSN: 0167-594X (Print) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : New York : Springer
      Original Publication: Boston : M. Nijhoff, 1983-
    • Subject Terms:
      Antimetabolites, Antineoplastic/*adverse effects ; Breast Neoplasms/*drug therapy ; Fluorouracil/*adverse effects ; Optic Nerve Diseases/*chemically induced; Aged ; Breast Neoplasms/secondary ; Female ; Humans ; Visual Fields/drug effects
    • Abstract:
      We report the case of a 72-year-old woman suffering from bone metastatic breast cancer and treated with continuous intravenous 5 fluorouracil (5FU) chemotherapy, who presented with a bilateral asymmetric anterior optic neuropathy (ON). A deficiency of dihydropyrimidine dehydrogenase (DPD) was documented. Patients with DPD deficiency are at increased risk for developing unusual and/or severe toxicity to 5FU. We discuss the differential diagnosis of anterior ON and we suggest that 5FU can be responsible for optic nerve toxicity in patients with DPD deficiency.
    • Number of References:
      34
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    • Accession Number:
      0 (Antimetabolites, Antineoplastic)
      U3P01618RT (Fluorouracil)
    • Publication Date:
      Date Created: 20030315 Date Completed: 20030404 Latest Revision: 20220408
    • Publication Date:
      20231215
    • Accession Number:
      10.1023/a:1020613600826
    • Accession Number:
      12635664