Glomerular C4d deposition indicates in situ classic complement pathway activation, but is not a marker for lupus nephritis activity.

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  • Author(s): Kim SH;Kim SH; Jeong HJ
  • Source:
    Yonsei medical journal [Yonsei Med J] 2003 Feb; Vol. 44 (1), pp. 75-80.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Yonsei University Country of Publication: Korea (South) NLM ID: 0414003 Publication Model: Print Cited Medium: Print ISSN: 0513-5796 (Print) Linking ISSN: 05135796 NLM ISO Abbreviation: Yonsei Med J Subsets: MEDLINE
    • Publication Information:
      Original Publication: Seoul : Yonsei University
    • Subject Terms:
      Complement C4b*; Complement C4/*metabolism ; Complement Pathway, Classical/*physiology ; Kidney Glomerulus/*metabolism ; Lupus Nephritis/*physiopathology ; Peptide Fragments/*metabolism; Adolescent ; Adult ; Biomarkers ; Child ; Female ; Humans ; Male ; Middle Aged ; Severity of Illness Index
    • Abstract:
      This study was designed to evaluate whether glomerular C4d deposition may be a useful marker of lupus nephritis activity. Twenty-one patients diagnosed as having lupus nephritis (WHO class III: 4 cases; IV: 12 cases; V: 5 cases) were included. Mean patient age was 29.3 +/- 13.5 years (range: 7-55 years). The presence and intensity of glomerular C4d deposition were compared with the corresponding histologic activity index for each case. Immunofluorescence for C4d showed diffusely granular staining along glomerular capillary loops, in all cases examined (1+, in 8 cases; 2+, in 7 cases; 3+, in 6 cases). In eight cases, C4d deposition was found in the absence of capillary or mesangial C4 deposits. Moreover, the intensity of C4d deposits correlated with those of capillary IgG, IgA, C4, C1q, and fibrinogen deposits. However, C4d staining intensity did not correlate with the lupus nephritis activity index. Although glomerular capillary C4d deposition is a sensitive marker of classic complement pathway activation, it is not a sensitive marker for active lupus nephritis.
    • Accession Number:
      0 (Biomarkers)
      0 (Complement C4)
      0 (Peptide Fragments)
      80295-50-7 (Complement C4b)
      80295-52-9 (complement C4d)
    • Publication Date:
      Date Created: 20030306 Date Completed: 20030411 Latest Revision: 20151119
    • Publication Date:
      20250114
    • Accession Number:
      10.3349/ymj.2003.44.1.75
    • Accession Number:
      12619178