Myocardial infarction and transient ventricular dysfunction in an adolescent with sickle cell disease.

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  • Author(s): Deymann AJ;Deymann AJ; Goertz KK
  • Source:
    Pediatrics [Pediatrics] 2003 Feb; Vol. 111 (2), pp. E183-7.
  • Publication Type:
    Case Reports; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 0376422 Publication Model: Print Cited Medium: Internet ISSN: 1098-4275 (Electronic) Linking ISSN: 00314005 NLM ISO Abbreviation: Pediatrics Subsets: MEDLINE
    • Publication Information:
      Publication: Elk Grove Village Il : American Academy of Pediatrics
      Original Publication: Springfield, Ill., Thomas.
    • Subject Terms:
      Anemia, Sickle Cell/*complications ; Myocardial Infarction/*etiology ; Ventricular Dysfunction/*etiology; Acute Disease ; Adolescent ; Anemia, Sickle Cell/therapy ; Exchange Transfusion, Whole Blood ; Humans ; Male ; Myocardial Infarction/therapy ; Myocardial Ischemia/complications ; Myocardial Ischemia/therapy ; Ventricular Dysfunction/therapy
    • Abstract:
      We report a case of an adolescent who had sickle cell disease and previous evidence of myocardial damage and presented with abdominal pain and rapid progression to cardiogenic shock and subsequent development of myocardial infarction. To our knowledge, this represents only the second report of a case of acute myocardial ischemia and subsequent infarction resulting transient ventricular dysfunction reported in a child with sickle cell disease successfully treated with exchange transfusion. The pathophysiology of this complication remains unclear, and cardiac complications may remain undetected as lung, bone, and brain infarcts are more common and the pain associated with sickle cell crisis may mask the ischemic symptoms. Multiple factors may contribute to ischemia in addition to the presence of a vaso-occlusive crisis or infection. Acute or chronic myocardial ischemia are probably more prevalent than currently known.
    • Publication Date:
      Date Created: 20030204 Date Completed: 20030220 Latest Revision: 20190605
    • Publication Date:
      20231215
    • Accession Number:
      10.1542/peds.111.2.e183
    • Accession Number:
      12563093