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Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference.
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- Author(s): Gyertyán I;Gyertyán I; Gál K
- Source:
Neuroreport [Neuroreport] 2003 Jan 20; Vol. 14 (1), pp. 93-8.
- Publication Type:
Comparative Study; Journal Article
- Language:
English
- Additional Information
- Source:
Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100935 Publication Model: Print Cited Medium: Print ISSN: 0959-4965 (Print) Linking ISSN: 09594965 NLM ISO Abbreviation: Neuroreport Subsets: MEDLINE
- Publication Information:
Publication: London, England : Lippincott Williams & Wilkins
Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., [1990-
- Subject Terms:
- Abstract:
The importance of dopamine D3 receptors in reward related processes, especially in cocaine addiction, has been investigated extensively. However, in the reported studies a combination of different experimental conditions and different ligands have been used which renders the interpretation and comparison of the diverse results extremely difficult. Here, we report one comparative study investigating a wide range of dopamine D3 receptor ligands in one model of cocaine abuse: the place conditioning paradigm in rats. Of the antagonists tested, the moderately D3 selective nafadotride and the more selective SB-277011 did not produce any place conditioning effect while U-99194A caused place-preference. The most D3 selective agonist PD-128907, the less selective 7-OH-DPAT and the moderately selective partial agonist BP-897 all caused significant place aversion. None of the compounds influenced the cocaine-induced place preference. Results suggest the D3-preferring agonists could affect the reward mechanisms of the brain, however, modulation of D3 receptor function does not appear to be a significant mechanism for modifying the place conditioning effect of cocaine.
(Copyright 2003 Lippincott Williams & Wilkins)
- Accession Number:
0 (Benzazepines)
0 (Benzopyrans)
0 (Dopamine Agonists)
0 (Dopamine Antagonists)
0 (Dopamine D2 Receptor Antagonists)
0 (Drd3 protein, rat)
0 (Indans)
0 (Naphthalenes)
0 (Nitriles)
0 (Oxazines)
0 (Piperazines)
0 (Pyrrolidines)
0 (Quinolines)
0 (Receptors, Dopamine D1)
0 (Receptors, Dopamine D2)
0 (Receptors, Dopamine D3)
0 (SB 277011)
0 (Tetrahydroisoquinolines)
0 (Tetrahydronaphthalenes)
123594-64-9 (3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol)
153570-58-2 ((5,6-dimethoxyindan-2-yl)dipropylamine)
20PLE5W821 (BP 897)
I5Y540LHVR (Cocaine)
J6292F8L3D (Haloperidol)
JP25MZ26IQ (nafadotride)
RR7D75YDF4 (7-hydroxy-2-N,N-dipropylaminotetralin)
- Publication Date:
Date Created: 20030125 Date Completed: 20030425 Latest Revision: 20191210
- Publication Date:
20240829
- Accession Number:
10.1097/00001756-200301200-00018
- Accession Number:
12544838
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