Non-permanent proteins in membranes: when proteins come as visitors (Review).

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  • Author(s): Goñi FM;Goñi FM
  • Source:
    Molecular membrane biology [Mol Membr Biol] 2002 Oct-Dec; Vol. 19 (4), pp. 237-45.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 9430797 Publication Model: Print Cited Medium: Print ISSN: 0968-7688 (Print) Linking ISSN: 09687688 NLM ISO Abbreviation: Mol Membr Biol Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: London, UK : Taylor & Francis, c1994-2019.
    • Subject Terms:
      Escherichia coli Proteins*; Intracellular Membranes/*metabolism ; Lipid Bilayers/*metabolism ; Membrane Proteins/*metabolism; Adenosine Triphosphatases/metabolism ; Bacterial Outer Membrane Proteins/metabolism ; Humans ; Sphingomyelin Phosphodiesterase/metabolism
    • Abstract:
      The present review introduces the concept of 'non-permanent membrane proteins', to encompass the wide variety of proteins that are not found in a stable membrane-bound form under physiological conditions, yet they interact with the membrane at some stage of their specific course of action. Non-permanent membrane proteins can be codified by the cell's own genome, or else they may arise from a foreign genome. Non-permanent membrane proteins can be classified, according to the reversibility of the membrane interaction, into those with reversible and irreversible (very long-lived) membrane contacts. According to the nature (strength) of the interaction, non-permanent membrane proteins may be divided into those that interact weakly with the membrane, in an extrinsic-like form, and those that interact strongly with the membrane. The latter can in turn be classified into those that cause and those that do not cause covalent modification of the lipids, the latter behaving, after interacting with the membrane, in the way of the conventional intrinsic proteins. Multiple examples are provided for the different groups of non-permanent membrane proteins, and a more detailed description is given of three of them, representative of different groups, namely TrwD from plasmid R388, E. coli alpha-haemolysin and B. cereus sphingomyelinase.
    • Number of References:
      63
    • Accession Number:
      0 (Bacterial Outer Membrane Proteins)
      0 (Escherichia coli Proteins)
      0 (Lipid Bilayers)
      0 (Membrane Proteins)
      EC 3.1.4.12 (Sphingomyelin Phosphodiesterase)
      EC 3.6.1.- (Adenosine Triphosphatases)
      EC 3.6.1.- (TrwD protein, E coli)
    • Publication Date:
      Date Created: 20030107 Date Completed: 20030618 Latest Revision: 20061115
    • Publication Date:
      20231215
    • Accession Number:
      10.1080/0968768021000035078
    • Accession Number:
      12512770