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The spectrum of pseudomembranous enterocolitis and antibiotic-associated diarrhea.
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- Author(s): Hurley BW;Hurley BW; Nguyen CC
- Source:
Archives of internal medicine [Arch Intern Med] 2002 Oct 28; Vol. 162 (19), pp. 2177-84.
- Publication Type:
Journal Article; Review
- Language:
English
- Additional Information
- Source:
Publisher: American Medical Assn Country of Publication: United States NLM ID: 0372440 Publication Model: Print Cited Medium: Print ISSN: 0003-9926 (Print) Linking ISSN: 00039926 NLM ISO Abbreviation: Arch Intern Med Subsets: MEDLINE
- Publication Information:
Original Publication: Chicago, American Medical Assn.
- Subject Terms:
- Abstract:
Pseudomembranous (entero)colitis is primarily caused by Clostridium difficile infection. The most common predisposing factor is prior use of antibiotics, including vancomycin and metronidazole, which themselves are therapy for C difficile colitis. Other risk factors have also been described. The presence of C difficile in the gastrointestinal tract leads to a spectrum of manifestations from the asymptomatic carrier state to fulminant colitis. Successful treatment of C difficile colitis requires prompt treatment with appropriate antibiotics, withdrawal of the suspected predisposing antibiotics, and, in rare cases, total colectomy. Preventive measures of adequate infection control and judicious use of antibiotics are necessary means in attempting to control the spread of C difficile infection. Attempts at making an effective human vaccine are currently under way.
- Number of References:
32
- Accession Number:
0 (Anti-Bacterial Agents)
- Publication Date:
Date Created: 20021024 Date Completed: 20021122 Latest Revision: 20201208
- Publication Date:
20240829
- Accession Number:
10.1001/archinte.162.19.2177
- Accession Number:
12390059
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