Maternal-fetal effects of magnesium sulfate on serum osmolality in pre-eclampsia.

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  • Author(s): van der Heyden JJ;van der Heyden JJ; Standley CA
  • Source:
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2002 Apr; Vol. 11 (4), pp. 270-4.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print Cited Medium: Print ISSN: 1476-7058 (Print) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: Boca Raton : Parthenon Pub. Group, c2002-
    • Subject Terms:
      Osmolar Concentration*; Fetal Blood/*drug effects ; Magnesium Sulfate/*pharmacokinetics ; Maternal-Fetal Exchange/*drug effects ; Pre-Eclampsia/*drug therapy ; Pregnancy/*physiology ; Tocolytic Agents/*pharmacokinetics; Adolescent ; Adult ; Female ; Fetus/physiology ; Fetus/physiopathology ; Humans ; Infusions, Intravenous ; Magnesium Sulfate/therapeutic use ; Tocolytic Agents/therapeutic use
    • Abstract:
      Objective: To determine the effects of magnesium sulfate therapy on maternal and fetal osmolality in pre-eclampsia.
      Methods: A total of 34 pre-eclamptic women and 22 normal pregnant women participated in the study. Venous blood was drawn upon admission to the labor and delivery unit. Pre-eclamptic patients received standard magnesium sulfate therapy and had a second sample of venous blood drawn 4 h following the beginning of therapy. Fetal umbilical vein blood was obtained immediately following delivery in both groups. Osmolality was measured using a vapor pressure osmometer. Electrolyte levels were measured with a NOVA 8 biomedical analyzer. Data were analyzed via Student's t test, linear regression and correlation with significance established at p < 0.05.
      Results: We found no significant difference between the maternal osmolalities of the control and pre-eclamptic groups. Interestingly, fetal cord blood osmolality was significantly lower than maternal osmolality in the normal pregnant women. Sodium levels were also lower, while potassium and ionized calcium levels were higher in the fetal blood. In women with pre-eclampsia treated with magnesium sulfate, there was no difference between the osmolality of the maternal and fetal blood, while potassium and ionized calcium levels were still higher in the fetal blood. Finally, we found no correlation between maternal osmolality and blood pressure.
      Conclusions: High blood pressure in pre-eclampsia is not associated with altered osmolality. An absence of the normal decrease in fetal osmolality is observed in pre-eclamptic women treated with magnesium sulfate.
    • Accession Number:
      0 (Tocolytic Agents)
      7487-88-9 (Magnesium Sulfate)
    • Publication Date:
      Date Created: 20021012 Date Completed: 20030221 Latest Revision: 20041117
    • Publication Date:
      20231215
    • Accession Number:
      10.1080/jmf.11.4.270.274
    • Accession Number:
      12375684