The Effect of Acute MDMA Administration on Body Temperature, Serum Corticosterone and Neurotransmitter Concentrations in Male and Female Rats.

The aim of this study was to examine the effect of acute administration on ± )3,4methylenedioxymethamphetamine (MDMA) (20 mg/kg, i.p.) on colonic temperature, serum corticosterone and brain biogenic amine concentrations in group-housed male and female. rats and to determine if there are any gender differences in susceptibility to MDMA- induced changes. Prior to treatment, basal colonic temperatures were higher in female than in male rats (p < 0.05). Temperatures were significantly increased 30 mm Following MDMA (20 mg,kg. i.p.) in male rats (p <0.05), and 120 mm following MDMA in female rats (p < 0.05). and were still elevated 240 mm following MDMA administration in both sexes. Basal corticosterone concentrations were also higher in female than in male rats (p < 0.05).. prior to treatment. Serum corticosterone concentrations were significantly elevated in both male and female rates 15 mm after MDMA administration (p < 0.05). and remained elevated For up to 4 h following MDMA (p < 0.001) and p.< 0-05 respectively). 5-Hydroxyl (5-HT) and 5-hydroxy-indole-3-acetic acid (5-HIAA) concentrations were significantly depleted in the frontal cortex, hypothalamus and striatum of both male and Female rats. However, pineat 5-HT was resistant to dupleüon by MDMA in both male and female rats- The 5-HIAA concentration was significantly reduced in the pineal gland of Female rats, probably due to decreased catabolism of pineal 5-UT. There was a profound decrease in the ratio 5-HT/5-HIAA in the frontal cortex but no changes occurred in these ratios in the striaturn, hypothalamus or pineal gland in either male or female rats. Dopamine (DA) concentrations were increased and 3.4-dihydroxyphenyl-acetic acid (DOPAC) levels decreased in the striatum in both male and female rats 4 h after MDMA administration. [ABSTRACT FROM AUTHOR]

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