[Activation of key proenzymes of the blood coagulation system by the fibrin E fragment].

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  • Additional Information
    • Transliterated Title:
      Aktyvatsiia kliuchovykh profermentiv systemy zsidannia krovi frahmentom E fibrynu.
    • Source:
      Publisher: Nat︠s︡ionalʹna akademii︠a︡ nauk Ukraïny, Instytut biokhimiï im. O.V. Palladina Country of Publication: Ukraine NLM ID: 101657175 Publication Model: Print Cited Medium: Print NLM ISO Abbreviation: Ukr Biokhim Zh (1999) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Kyïv : Nat︠s︡ionalʹna akademii︠a︡ nauk Ukraïny, Instytut biokhimiï im. O.V. Palladina, 1999-2013.
    • Subject Terms:
      Blood Coagulation Factors/*metabolism ; Enzyme Precursors/*metabolism ; Fibrin Fibrinogen Degradation Products/*metabolism; Catalysis ; Coagulase/metabolism ; Humans ; Streptokinase/metabolism ; Thrombolytic Therapy
    • Abstract:
      Plasminogen and prothrombin are key proenzymes of fibrinolytic and clotting system. It is known that they can be activated by indirect activators streptokinase and staphylocoagulase. In this paper it is shown that fibrin E fragment purified from DD-E complex induced catalytic activity in plasminogen and clotting activity in prothrombin. Streptokinase increased 2 times the rate of catalytic activity induction by E fragment in prothrombin. It's possibly that process is one of the factors providing for rethrombosis after thrombolytic therapy of myocardial infarction.
    • Accession Number:
      0 (Blood Coagulation Factors)
      0 (Coagulase)
      0 (Enzyme Precursors)
      0 (Fibrin Fibrinogen Degradation Products)
      EC 3.4.- (Streptokinase)
    • Publication Date:
      Date Created: 20020803 Date Completed: 20021011 Latest Revision: 20150803
    • Publication Date:
      20240829
    • Accession Number:
      12152309