Vitamin D supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status.

BLOOD pressure; CALCIUM; CARDIOVASCULAR diseases risk factors; DIET therapy; DIETARY supplements; GENE expression; RESEARCH funding; STATISTICS; T-test (Statistics); VITAMIN D; VITAMIN D deficiency; DATA analysis; CHOLECALCIFEROL; RANDOMIZED controlled trials; BLIND experiment; DATA analysis software; NUTRITIONAL status; MANN Whitney U Test

AUSTRIA; GERMANY; SWITZERLAND

Purpose: The Nutrition Societies in Germany, Austria, and Switzerland recommend a daily intake of 20 µg vitamin D for adults when endogenous synthesis is absent. The current study aimed to elucidate whether this vitamin D dose impacts cardiovascular risk markers of adults during the winter months. Methods: The study was conducted in Halle (Saale), Germany (51 northern latitude) as a placebo-controlled, double-blinded, randomised trial (from January to April). A total of 105 apparently healthy subjects (male and female, 20-71 years old) were included. Subjects were randomly allocated to two groups. One group received a daily 20-µg vitamin D dose ( n = 54), and the other group received a placebo ( n = 51) for 12 weeks. Outcome measures included blood pressure, heart rate, concentrations of renin, aldosterone, serum lipids and vascular calcification markers, and haematologic variables such as pro-inflammatory monocytes. Results: Blood pressure and systemic cardiovascular risk markers remained unchanged by vitamin D supplementation, although serum 25-hydroxyvitamin D increased from 38 ± 14 to 73 ± 16 nmol/L at week 12. The placebo and vitamin D groups did not differ in their final cardiovascular risk profile. Conclusion: Daily supplementation of 20 µg vitamin D during winter is unlikely to change cardiovascular risk profile. [ABSTRACT FROM AUTHOR]