3-Hidroksipiridin-4-oni (II. dio): Biološka primjena kao kelatora željeza. (Croatian)

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    • Alternate Title:
      3-Hydroxypyridin-4-ones (Part II): Biological Application as Iron Chelating Agents. (English)
    • Abstract:
      Selectivity towards trivalent metal cations, especially Fe(III), is the primary basis of a number of 3-hydroxypyridin-4-ones' biological activities. These compounds have high potential in the treatment of iron overload diseases, in various blood pathologies such as thalassemia and hemochromatosis, as well as in the treatment of neurodegenerative diseases, such as Alzheimer's disease. Beside deferiprone, the only 3-hydroxypyridin-4-one based iron(III) chelating agent which has been used clinically for more than 30 years, this review will also present other most significant and potentially biologically active chelators with 3-hydroxypyridin-4-one core. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Selektivnost prema keliranju trovalentnih kationa metala, u prvom redu Fe(III), osnova je brojnih bioloških učinaka derivata 3-hidroksipiridin-4-ona. Ti spojevi najviše potencijala pokazuju u liječenju oboljenja uslijed kojih dolazi do nakupljanja željeza u organizmu, kao što su razna krvna oboljenja poput talasemije i hemokromatoze te u liječenju neurodegenerativnih bolesti, primjerice Alzheimerove bolesti. Osim deferiprona, koji je već više od 30 godina u kliničkoj upotrebi kao kelator Fe(III), u ovom radu dan je pregled i ostalih najznačajnijih kelatora 3-hidroksipiridin-4-onske strukture s potencijalnom biološkom primjenom. [ABSTRACT FROM AUTHOR]
    • Abstract:
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