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Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
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Village Library
9 a.m. - 6 p.m.
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Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
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9 a.m. - 8 p.m.
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McClellanville Library
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Part I: Pituitary adenylate cyclase-activating polypeptide-38 induced migraine-like attacks in patients with and without familial aggregation of migraine.
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- Author(s): Song Guo; Haulund Vollesen, Anne Luise; Esserlind, Ann-Louise; Mohammed Amin, Faisal; Francke Christensen, Anne; Olesen, Jes; Ashina, Messoud; Hansen, Rikke Dyhr; Guo, Song (AUTHOR); Vollesen, Anne Luise Haulund (AUTHOR); Amin, Faisal Mohammed (AUTHOR); Christensen, Anne Francke (AUTHOR)
- Source:
Cephalalgia. Feb2017, Vol. 37 Issue 2, p125-135. 11p. 1 Diagram, 5 Charts, 2 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: Background Intravenous infusion of adenylate cyclase-activating polypeptide-38 (PACAP38) provokes migraine-like attacks in 65-70% of migraine sufferers. Whether aggregation of migraine in first-degree relatives contributes to this discrepancy in PACAP38-induced response is unknown. We hypothesized that genetic enrichment plays a role in triggering of migraine and that migraine without aura patients with a high family load ( ≥ 2 first-degree relatives with migraine) would report more migraine-like attacks after intravenous infusion of human PACAP38. Methods In this study, we allocated 32 previously genotyped migraine without aura patients to receive intravenous infusion of 10 pmol/kg/min PACAP38 and recorded migraine-like attacks including headache characteristics and associated symptoms. Information of familial aggregation was obtained by telephone interview of first-degree relatives using a validated semi-structured questionnaire. Results PACAP38 infusion induced a migraine-like attack in 75% (nine out of 12) of patients with high family load compared to 70% (14 out of 20) with low family load ( P = 0.761). In an explorative investigation, we found that the migraine response after PACAP38 was not associated with the risk allele of rs2274316 ( MEF2D), which confers increased risk of migraine without aura and may regulate PACAP38 expression. Conclusion Migraine response to PACAP38 infusion in migraine without aura patients is not associated with high family load or the risk allele of rs2274316 ( MEF2D). [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Cephalalgia is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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