The Antigenicity of the Tumor Cell - Context Matters.

TUMORS; IMMUNOTHERAPY; T cells; T cell receptors; MESSENGER RNA; MELANOMA treatment; ANTIGENS; BLOOD donors; CELL receptors; LYMPHOCYTES; MELANOMA; GENETIC mutation; RNA; TUMOR antigens

The article focuses on antigenicity of tumor cells. Topics discussed include importance on efficiency of immunotherapies that are designed to boost patient's immune system; disappearance of T cells responsive to neoantigens in patients treated with adoptive T cell therapy; and recognition of autologous tumors by T cell receptors. Other topics include synthesis of messenger RNA fragments corresponding to the putative neoantigens, and a diagram representing outsourcing cancer immunity.