[Interaction between acyclic phenol--formaldehyde oligomers and quaternary ammonium ions].

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  • Author(s): Ito K;Ito K; Miki H; Ohba Y
  • Source:
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2002 Jun; Vol. 122 (6), pp. 413-7.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Nihon Yakugakkai Country of Publication: Japan NLM ID: 0413613 Publication Model: Print Cited Medium: Print ISSN: 0031-6903 (Print) Linking ISSN: 00316903 NLM ISO Abbreviation: Yakugaku Zasshi Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tokyo : Nihon Yakugakkai
    • Subject Terms:
      Alkanes*/chemistry ; Formaldehyde*/chemistry ; Quaternary Ammonium Compounds*/chemistry; Drug Interactions ; Hydrogen Bonding ; Magnetic Resonance Spectroscopy
    • Abstract:
      The interaction between acyclic phenol-formaldehyde oligomers (1) and quaternary ammonium ions (5) was investigated by 1H-NMR spectroscopy. From the induced chemical shift change of 5 in the presence of 1, the cation-pi interaction between the N(+)-(CH3)3 moiety of 5 and the pi-base of 1 occurs during the formation of the complex. Another important observation is that the OH proton signals of 1 are considerably broadened upon addition of 5, indicating that hydrogen bonding occurs between exchangeable protons of 1 and iodide anion of 5. These interactions play an important role in the binding of 5.
    • Accession Number:
      0 (Alkanes)
      0 (Quaternary Ammonium Compounds)
      0 (quaternary bisammonium salt)
      1HG84L3525 (Formaldehyde)
    • Publication Date:
      Date Created: 20020629 Date Completed: 20020730 Latest Revision: 20190724
    • Publication Date:
      20231215
    • Accession Number:
      10.1248/yakushi.122.413
    • Accession Number:
      12087780