Serotonergic modulation of visceral sensation: upper gastrointestinal tract.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Tack J;Tack J; Sarnelli G
  • Source:
    Gut [Gut] 2002 Jul; Vol. 51 Suppl 1, pp. i77-80.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print Cited Medium: Print ISSN: 0017-5749 (Print) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
    • Publication Information:
      Original Publication: London, British Medical Assn.
    • Subject Terms:
      Sensation/*physiology ; Serotonin/*physiology ; Visceral Afferents/*physiology; Animals ; Duodenum/physiology ; Dyspepsia/drug therapy ; Esophagus/physiology ; Humans ; Nociceptors/physiology ; Randomized Controlled Trials as Topic ; Receptors, Serotonin/metabolism ; Serotonin Antagonists/therapeutic use ; Stomach/physiology ; Visceral Afferents/drug effects
    • Abstract:
      Agents that modify serotonergic function have therapeutic potential for the treatment of visceral hypersensitivity, either through a direct effect on perception or through modulation of visceral tone or motility. Administration of selective serotonin reuptake inhibitors reduces oesophageal sensitivity to distension but not gastric sensitivity to distension. 5-HT ligands may also influence gastric mechanosensitivity by altering tone. Although the exact role of 5-HT receptors in the control of gastrointestinal functions remains unknown, 5-HT is generally considered to be the main candidate involved in the modulation of motor and sensory function from the gastrointestinal tract. Hence serotonergic modulation of upper gut sensitivity appears to be promising for the development of novel approaches to the treatment of functional disorders of the upper gastrointestinal tract.
    • Number of References:
      48
    • References:
      Am J Gastroenterol. 1998 Feb;93(2):160-5. (PMID: 9468233)
      Aliment Pharmacol Ther. 1999 May;13 Suppl 2:15-30. (PMID: 10429737)
      Verh K Acad Geneeskd Belg. 2000;62(3):183-207; discussion 207-10. (PMID: 10905119)
      Lancet. 2000 Sep 30;356(9236):1127-8. (PMID: 11030288)
      Gut. 2001 Jan;48(1):125-31. (PMID: 11115834)
      Aliment Pharmacol Ther. 2001 Apr;15(4):525-37. (PMID: 11284782)
      Gastroenterology. 2001 Sep;121(3):526-35. (PMID: 11522735)
      J Pharmacol Exp Ther. 1979 Mar;208(3):446-53. (PMID: 581884)
      Br J Pharmacol. 1979 May;66(1):7-9. (PMID: 313230)
      Annu Rev Neurosci. 1981;4:227-72. (PMID: 6111979)
      Gastroenterology. 1989 May;96(5 Pt 1):1257-64. (PMID: 2539305)
      Anat Rec. 1989 Jul;224(3):431-42. (PMID: 2476950)
      Gastroenterology. 1990 May;98(5 Pt 1):1193-8. (PMID: 2323512)
      Br J Pharmacol. 1990 Jul;100(3):497-501. (PMID: 2167734)
      Eur J Pharmacol. 1991 Nov 26;205(2):203-8. (PMID: 1812010)
      Am J Physiol. 1992 Dec;263(6 Pt 1):G838-46. (PMID: 1476191)
      Dig Dis Sci. 1993 Jun;38(6):1079-86. (PMID: 8508703)
      Am J Physiol. 1994 Feb;266(2 Pt 1):G230-8. (PMID: 8141296)
      N Engl J Med. 1994 May 19;330(20):1411-7. (PMID: 8159194)
      Gastroenterology. 1994 Jul;107(1):271-93. (PMID: 8020671)
      Gastroenterology. 1994 Nov;107(5):1345-51. (PMID: 7926499)
      Pharmacol Rev. 1994 Jun;46(2):157-203. (PMID: 7938165)
      Aliment Pharmacol Ther. 1994 Aug;8(4):403-7. (PMID: 7986965)
      Gastroenterology. 1995 Feb;108(2):330-6. (PMID: 7835573)
      J Neurosci. 1996 Apr 1;16(7):2352-64. (PMID: 8601815)
      Behav Brain Res. 1996;73(1-2):63-8. (PMID: 8788479)
      Am J Physiol. 1996 Oct;271(4 Pt 1):G591-7. (PMID: 8897877)
      Neurogastroenterol Motil. 1996 Dec;8(4):319-31. (PMID: 8959736)
      Gastroenterology. 1997 May;112(5):1714-43. (PMID: 9136853)
      J Neurosci. 1997 Oct 15;17(20):8009-17. (PMID: 9315919)
      Gut. 1998 Jun;42(6):807-13. (PMID: 9691919)
      Aliment Pharmacol Ther. 1998 Aug;12(8):761-6. (PMID: 9726390)
      Am J Physiol. 1998 Sep;275(3 Pt 1):G460-6. (PMID: 9724256)
      Aliment Pharmacol Ther. 1998 Sep;12(9):849-55. (PMID: 9768527)
      Gastroenterology. 1998 Dec;115(6):1346-52. (PMID: 9834261)
      Am J Physiol. 1999 Feb;276(2 Pt 1):G373-7. (PMID: 9950810)
      Cell Tissue Res. 1999 Jul;297(1):81-90. (PMID: 10398885)
      Gut. 2000 Apr;46(4):468-73. (PMID: 10716674)
    • Accession Number:
      0 (Receptors, Serotonin)
      0 (Serotonin Antagonists)
      333DO1RDJY (Serotonin)
    • Publication Date:
      Date Created: 20020622 Date Completed: 20020829 Latest Revision: 20190501
    • Publication Date:
      20221213
    • Accession Number:
      PMC1867718
    • Accession Number:
      10.1136/gut.51.suppl_1.i77
    • Accession Number:
      12077073