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Phase II study of uracil-tegafur in patients with metastatic pancreatic cancer.
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- Additional Information
- Source:
Publisher: Karger Country of Publication: Switzerland NLM ID: 0135054 Publication Model: Print Cited Medium: Print ISSN: 0030-2414 (Print) Linking ISSN: 00302414 NLM ISO Abbreviation: Oncology Subsets: MEDLINE
- Publication Information:
Original Publication: Basel, New York, Karger.
- Subject Terms:
- Abstract:
Objective: Uracil-tegafur (UFT) has been reported to have a broad anti-tumor activity in a variety of malignancies including colorectal cancer and breast cancer. However, its activity in pancreatic cancer has not been fully evaluated. The aim of the present study was to evaluate the anti-tumor activity and toxicity of UFT in patients with metastatic pancreatic cancer.
Methods: All patients were required to have a pathologic diagnosis of pancreatic adenocarcinoma with measurable metastatic lesions, and no prior chemotherapy. A dose of 360 mg/m2/day of UFT was administered orally until the appearance of disease progression or unacceptable toxicity.
Results: Twenty-two patients were entered into this study. Of 21 patients evaluable for response, no patient achieved an objective tumor response; one showed no change, and the remaining 20 showed progressive disease. The median survival time for all patients was 4.2 (range: 0.9-9.0) months. The most common toxicities were nausea/vomiting and anorexia. Five patients (23%) had to discontinue UFT treatment because of gastrointestinal toxicity.
Conclusion: This schedule of UFT did not demonstrate a significant anti-tumor activity against metastatic pancreatic cancer.
(Copyright 2002 S. Karger AG, Basel)
- Accession Number:
1548R74NSZ (Tegafur)
56HH86ZVCT (Uracil)
- Subject Terms:
1-UFT protocol
- Publication Date:
Date Created: 20020618 Date Completed: 20020719 Latest Revision: 20171101
- Publication Date:
20240829
- Accession Number:
10.1159/000059569
- Accession Number:
12065869
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