[Role of somatostatin in the management of upper gastrointestinal bleeding].

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  • Author(s): Herszényi L
  • Source:
    Orvosi hetilap [Orv Hetil] 2002 May 12; Vol. 143 (19 Suppl), pp. 1092-9.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Hungarian
  • Additional Information
    • Transliterated Title:
      A somatostatin szerepe a felsó tápcsatornai vérzések kezelésében.
    • Source:
      Publisher: Akademiai Kiado Country of Publication: Hungary NLM ID: 0376412 Publication Model: Print Cited Medium: Print ISSN: 0030-6002 (Print) Linking ISSN: 00306002 NLM ISO Abbreviation: Orv Hetil Subsets: MEDLINE
    • Publication Information:
      Publication: 2007- : Budapest : Akademiai Kiado
      Original Publication: Pest : Markusovszky Lajos
    • Subject Terms:
      Gastrointestinal Hemorrhage/*drug therapy ; Hemostatics/*therapeutic use ; Octreotide/*therapeutic use ; Somatostatin/*therapeutic use; Esophageal and Gastric Varices/complications ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/metabolism ; Hemostatics/pharmacology ; Hormones/therapeutic use ; Humans ; Octreotide/pharmacology ; Randomized Controlled Trials as Topic ; Somatostatin/pharmacology
    • Abstract:
      There exists a substantial basis of experimental and clinical data to support that somatostatin and its long acting synthetic analogue octreotide may be therapeutically efficacious either as primary or adjunctive therapy in subgroups of patients with upper gastrointestinal bleeding. It has been proposed that somatostatin represents the optimal drug treatment for acute variceal bleeding due to its efficacy, its simplicity of administration and its lack of significant side effects. It provides beneficial respite if endoscopic therapy cannot be performed immediately. Somatostatin also facilitates the performance of diagnostic and of non-pharmaceutic interventions. Despite strong theoretical evidence in support of the application of somatostatin to the control of acute nonvariceal gastrointestinal bleeding, clinical trials have yielded conflicting results.
    • Number of References:
      95
    • Accession Number:
      0 (Hemostatics)
      0 (Hormones)
      51110-01-1 (Somatostatin)
      RWM8CCW8GP (Octreotide)
    • Publication Date:
      Date Created: 20020618 Date Completed: 20020702 Latest Revision: 20131121
    • Publication Date:
      20221213
    • Accession Number:
      12063868