Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.

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  • Author(s): Wilson ME;Wilson ME; Kalamaras JA; German MS
  • Source:
    Mechanisms of development [Mech Dev] 2002 Jul; Vol. 115 (1-2), pp. 171-6.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Ireland NLM ID: 9101218 Publication Model: Print Cited Medium: Print ISSN: 0925-4773 (Print) Linking ISSN: 09254773 NLM ISO Abbreviation: Mech Dev Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier
      Original Publication: Shannon : Elsevier Scientific Publishers Ireland, c1991-
    • Subject Terms:
      DNA-Binding Proteins* ; Gene Expression* ; Homeodomain Proteins* ; Nerve Tissue Proteins* ; Proprotein Convertase 1*; Amyloid/*genetics ; Aspartic Acid Endopeptidases/*genetics ; Pancreas/*enzymology; Animals ; Embryonic and Fetal Development ; Gene Expression Profiling ; Glucagon/metabolism ; Insulin/metabolism ; Islet Amyloid Polypeptide ; Mice ; POU Domain Factors ; Pancreas/cytology ; Pancreas/embryology ; Proprotein Convertases ; Trans-Activators/genetics ; Transcription Factors/genetics
    • Abstract:
      The earliest endocrine cells in the developing pancreas make glucagon and are described as alpha cells. We show here that these cells express islet amyloid polypeptide and prohormone convertase 1/3 (PC1/3), proteins that are not expressed by mature alpha cells, but are found in beta cells. PC1/3 converts proglucagon to the functionally distinct hormones glucagon-like peptide (GLP)-1 and GLP-2 rather than glucagon. Despite these differences, the early proglucagon-positive cells express, as do mature alpha cells, the POU domain transcription factor Brn-4, and do not express the beta cell factor pdx-1. The early production of atypical peptide hormones by these cells suggests that they could play an important role locally or systemically in the development of the embryo.
    • Grant Information:
      R01 DK021344 United States DK NIDDK NIH HHS; R01 DK 55340.03 United States DK NIDDK NIH HHS; R01 DK21344 United States DK NIDDK NIH HHS
    • Accession Number:
      0 (Amyloid)
      0 (DNA-Binding Proteins)
      0 (Homeodomain Proteins)
      0 (Insulin)
      0 (Islet Amyloid Polypeptide)
      0 (Nerve Tissue Proteins)
      0 (POU Domain Factors)
      0 (Trans-Activators)
      0 (Transcription Factors)
      0 (pancreatic and duodenal homeobox 1 protein)
      147258-09-1 (Pou3f4 protein, mouse)
      9007-92-5 (Glucagon)
      EC 3.4.21.- (Proprotein Convertases)
      EC 3.4.21.93 (Pcsk1 protein, mouse)
      EC 3.4.21.93 (Proprotein Convertase 1)
      EC 3.4.23.- (Aspartic Acid Endopeptidases)
    • Publication Date:
      Date Created: 20020607 Date Completed: 20030127 Latest Revision: 20190910
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/s0925-4773(02)00118-1
    • Accession Number:
      12049785