Simultaneous glyburide/metformin therapy is superior to component monotherapy as an initial pharmacological treatment for type 2 diabetes.

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  • Author(s): Garber AJ;Garber AJ; Larsen J; Schneider SH; Piper BA; Henry D
  • Source:
    Diabetes, obesity & metabolism [Diabetes Obes Metab] 2002 May; Vol. 4 (3), pp. 201-8.
  • Publication Type:
    Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Corporate Authors:
      Glyburide/Metformin Initial Therapy Study Group
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print Cited Medium: Print ISSN: 1462-8902 (Print) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Wiley-Blackwell, c1999-
    • Subject Terms:
      Blood Glucose/*metabolism ; Diabetes Mellitus, Type 2/*drug therapy ; Glyburide/*therapeutic use ; Hypoglycemic Agents/*therapeutic use ; Metformin/*therapeutic use; Blood Glucose/drug effects ; Body Weight/drug effects ; Diabetes Mellitus, Type 2/blood ; Drug Therapy, Combination ; Fasting ; Female ; Glyburide/adverse effects ; Humans ; Hypoglycemic Agents/adverse effects ; Male ; Metformin/adverse effects ; Middle Aged ; Placebos ; Postprandial Period ; Racial Groups ; Safety ; United States
    • Abstract:
      Objective: To evaluate whether simultaneous initial treatment of both insulin resistance and impaired beta-cell insulin secretion with glyburide/metformin tablets is superior to monotherapy with each component agent.
      Research Design and Methods: In this randomized, parallel-group, placebo-controlled, multicentre study, 806 patients with type 2 diabetes (mean duration, 3 years) who had failed diet and exercise were randomly assigned to 4 weeks of therapy with placebo, glyburide 2.5 mg, metformin 500 mg, glyburide/metformin 1.25/250 mg, or glyburide/metformin 2.5/500 mg once daily. Doses were then titrated over 8 weeks based on glycaemic response. The primary outcome measure was change from baseline in mean HbA1c after 20 weeks. Changes in fasting plasma glucose, lipids and body weight were also assessed along with 2-h postprandial glucose and insulin values after a standardized meal.
      Results: At week 20, patients taking glyburide/metformin 1.25/250 mg or 2.5/500 mg tablets had greater reductions in HbA1c levels (-1.48% and -1.53% respectively) compared with placebo (-0.21%; both p < 0.001), glyburide (-1.24%; p = 0.016 and p = 0.004 respectively) or metformin (-1.03%; both p < 0.001). Fasting plasma glucose concentrations were reduced more in both glyburide/metformin groups compared with placebo and metformin (p < 0.001); patients in both combination therapy groups also had significantly lower postprandial glucose concentrations compared with placebo, glyburide and metformin.
      Conclusions: Initial combination treatment with glyburide/metformin tablets produces greater improvements in glycaemic control than either glyburide or metformin monotherapy. The superiority of initial therapy with glyburide/metformin tablets may arise from simultaneous treatment of both pathophysiological defects of type 2 diabetes.
    • Comments:
      Erratum in: Diabetes Obes Metab. 2002 Jul;4(4):286..
    • Accession Number:
      0 (Blood Glucose)
      0 (Hypoglycemic Agents)
      0 (Placebos)
      9100L32L2N (Metformin)
      SX6K58TVWC (Glyburide)
    • Publication Date:
      Date Created: 20020606 Date Completed: 20021010 Latest Revision: 20211203
    • Publication Date:
      20240627
    • Accession Number:
      10.1046/j.1463-1326.2002.00211.x
    • Accession Number:
      12047399