[Effect of products of germ-line and somatic gene mutations on chromatin remodeling].

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  • Author(s): Smardová J;Smardová J; Smarda J
  • Source:
    Casopis lekaru ceskych [Cas Lek Cesk] 2002 Mar 01; Vol. 141 (4), pp. 112-7.
  • Publication Type:
    English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    Czech
  • Additional Information
    • Transliterated Title:
      Důsledky vrozených a somatických mutací genů, jejichz produkty se úcastní prestavby chromatinu.
    • Source:
      Publisher: Ceskoslovenska Lekarska Spolecnost Country of Publication: Czech Republic NLM ID: 0004743 Publication Model: Print Cited Medium: Print ISSN: 0008-7335 (Print) Linking ISSN: 00087335 NLM ISO Abbreviation: Cas Lek Cesk Subsets: MEDLINE
    • Publication Information:
      Original Publication: Praha : Ceskoslovenska Lekarska Spolecnost
    • Subject Terms:
      Mutation*; Chromatin/*genetics ; Chromatin/*metabolism; Genetic Therapy ; Germ-Line Mutation ; Histones/genetics ; Histones/metabolism ; Humans ; Leukemia/genetics ; Neoplasms/genetics ; Neoplasms/therapy
    • Abstract:
      Chromatin remodeling is engaged in basic cell functions as DNA replication, recombination, DNA repair and transcription of genes. Chromatin is remodeled by ATP-dependent chromatin remodeling complexes and protein complexes covalently modifying histones. Germ-line mutations of the genes coding for proteins which participate in chromatin remodeling cause severe developmental diseases and they increase a risk of cancer development. Somatic mutations and translocations of such genes are associated with cancer development of certain tumors. Chromatin remodeling mechanisms can thus be targeted by special strategy of cancer therapy.
    • Number of References:
      44
    • Accession Number:
      0 (Chromatin)
      0 (Histones)
    • Publication Date:
      Date Created: 20020606 Date Completed: 20020620 Latest Revision: 20121115
    • Publication Date:
      20221213
    • Accession Number:
      12046254