The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl.

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  • Author(s): Memiş D;Memiş D; Turan A; Karamanlioğlu B; Süt N; Pamukçu Z
  • Source:
    Anesthesia and analgesia [Anesth Analg] 2002 Jun; Vol. 94 (6), pp. 1517-20, table of contents.
  • Publication Type:
    Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1310650 Publication Model: Print Cited Medium: Print ISSN: 0003-2999 (Print) Linking ISSN: 00032999 NLM ISO Abbreviation: Anesth Analg Subsets: MEDLINE
    • Publication Information:
      Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins
      Original Publication: Cleveland, International Anesthesia Research Society.
    • Subject Terms:
      Analgesics, Opioid/*therapeutic use ; Androstanols/*adverse effects ; Anesthetics, Local/*therapeutic use ; Fentanyl/*therapeutic use ; Lidocaine/*therapeutic use ; Neuromuscular Nondepolarizing Agents/*adverse effects ; Ondansetron/*therapeutic use ; Pain/*prevention & control ; Serotonin Antagonists/*therapeutic use ; Tramadol/*therapeutic use; Adult ; Androstanols/administration & dosage ; Double-Blind Method ; Female ; Humans ; Injections/adverse effects ; Male ; Neuromuscular Nondepolarizing Agents/administration & dosage ; Pain/etiology ; Pain Measurement/drug effects ; Rocuronium
    • Abstract:
      Unlabelled: We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing pain caused by the injection of rocuronium in 250 patients. After tourniquet application on the forearm, the patients were given saline (3 mL) (Group 1, n = 50), ondansetron (4 mg) (Group 2, n = 50), lidocaine (30 mg) (Group 3, n = 50), tramadol (50 mg) (Group 4, n = 50), or fentanyl (100 microg) (Group 5, n = 50) diluted into a 3-mL solution. The occlusion was released after 20 s and rocuronium was injected over 10-15 s. The patients were observed and asked immediately if they had pain in the arm, and the response was assessed. Reactions such as discomfort and pain, withdrawal of the hand, and so on after the administration of rocuronium were recorded as side effects for 24 h. Ten patients in Group 1, 28 patients in Group 2, 37 patients in Group 3, 30 patients in Group 4, and 15 patients in Group 5 reported no pain. Light pain was seen in 11 patients in Group 1, 14 patients in Group 2, 11 patients in Group 3, 12 patients in Group 4, and 20 patients in Group 5. Moderate pain was seen in 15 patients in Group 1, 6 patients in Group 2, 2 patients in Group 3, 8 patients in Group 4, and 10 patients in Group 5. Severe pain was seen in 14 patients in Group 1, 2 patients in Group 2, 0 patients in Group 3, 0 patients in Group 4, and 5 patients in Group 5. Correlation determined with log-linear analysis found in Group 1 pain score 0 (P < 0.001), Group 1 pain score 1 (P < 0.001), and Group 3 pain score 0 (P < 0.001). We conclude that ondansetron, lidocaine, tramadol, and fentanyl decrease the level of rocuronium injection pain. Among these drugs, lidocaine is the most effective, whereas fentanyl is the least effective.
      Implications: We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing the pain on injection of rocuronium in 250 patients. Ondansetron, lidocaine, tramadol, and fentanyl were effective in preventing and decreasing the level of rocuronium injection pain. Among these drugs, lidocaine was the most effective, and fentanyl was the least effective.
    • Accession Number:
      0 (Analgesics, Opioid)
      0 (Androstanols)
      0 (Anesthetics, Local)
      0 (Neuromuscular Nondepolarizing Agents)
      0 (Serotonin Antagonists)
      39J1LGJ30J (Tramadol)
      4AF302ESOS (Ondansetron)
      98PI200987 (Lidocaine)
      UF599785JZ (Fentanyl)
      WRE554RFEZ (Rocuronium)
    • Publication Date:
      Date Created: 20020529 Date Completed: 20020619 Latest Revision: 20220331
    • Publication Date:
      20221213
    • Accession Number:
      10.1097/00000539-200206000-00026
    • Accession Number:
      12032018