Advanced light microscopy enables rapid mapping of brain structure and function in high resolution.

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    • Abstract:
      The article focuses on the developments in light-sheet microscopy (LSM), CLARITY-optimized light-sheet microscopy (COLM) and spherical aberrations-assisted extended depth-of-field (SPED). It relates that COLM and SPED are easing significant developments in neuroscience by enabling brain-wide mapping of structure and function, and their interrelationships.