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Edgar Allan Poe/Sullivan's Island Library
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Urban Dust Microbiome: Impact on Later Atopy and Wheezing.
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- Author(s): Tischer, Christina1,2,3,4 ; Weikl, Fabian5; Probst, Alexander J.6; Standl, Marie1; Heinrich, Joachim1,7; Pritsch, Karin5
- Source:
Environmental Health Perspectives. Dec2016, Vol. 124 Issue 12, p1919-1923. 5p. 2 Charts, 1 Map.- Subject Terms:
*Allergies; *Dust; *Indoor air pollution; Physiological effects of dust; Asthma risk factors; Air microbiology; DNA analysis; Bacteriophage typing; Confidence intervals; Longitudinal method; Evaluation of medical care; Metropolitan areas; Polymerase chain reaction; Probability theory; Research funding; Logistic regression analysis; Data analysis software; Descriptive statistics; Mycological typing techniques; Odds ratio; Children - Source:
- Additional Information
- Subject Terms:
- Abstract: BACKGROUND: Investigations in urban areas have just begun to explore how the indoor dust microbiome may affect the pathogenesis of asthma and allery. OBJECTIVE: We aimed to investigate the early fungal and bacterial microbiome in house dust with allergic sensitization and wheezing later in childhood. METHODS: Individual dust samples from 189 homes of the LISAplus birth cohort study were collected shortly after birth from living room floors and profiled for fungal and bacterial microbiome. Fungal and bacterial diversity was assessed with terminal restriction fragment length polymorphism (tRFLP) and defined by Simpson's Diversity Index. Information on wheezing outcomes and covariates until the age of 10 years was obtained by parent questionnaires. Information on specific allergic sensitization was available at child's age 6 and 10 years. Logistic regression and general estimation equation (GEE) models were used to examine the relationship between microbial diversity and health outcomes. RESULTS: Adjusted logistic regression analyses revealed a significantly reduced risk of developing sensitization to aero-allergens at 6 years and ever wheezing until the age of 10 years for exposure to higher fungal diversity [adjusted odds ratio (aOR) = 0.26 (95% CI: 0.10, 0.70), and 0.42 (95% CI: 0.18, 0.96), respectively]. The associations were attenuated for the longitudinal analyses (GEE) until the age of 10 years. There was no association between higher exposure to bacterial diversity and the tested health outcomes. CONCLUSION: Higher early exposure to fungal diversity might help to prevent a child from developing sensitization to aero-allergens in early childhood, but the reasons for attenuated effects in later childhood require further prospective studies. CITATION: Tischer C, Weikl F, Probst AJ, Standi M, Heinrich J, Pritsch K. 2016. Urban dust microbiome: impact on later atopy and wheezing. Environ Health Perspect 124:1919 -- 1923; http://dx.doi.org/10.1289/EHP158 [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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