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Wando Mount Pleasant Library
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IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections.
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- Author(s): Slaats, Jeroen; ten Oever, Jaap; van de Veerdonk, Frank L.; Netea, Mihai G.
- Source:
PLoS Pathogens; 12/15/2016, Vol. 12 Issue 12, p1-13, 13p- Subject Terms:
- Source:
- Additional Information
- Abstract: The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases. This review discusses the profiles of acute-phase proteins and circulating cytokines encountered in viral and bacterial infections. We also propose a model in which the inflammatory response to viral (IL-18/ferritin) and bacterial (IL-6/CRP) infections presents with specific plasma patterns of immune biomarkers. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS Pathogens is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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