Perioperative hemodynamic and geometric changes of the left ventricle during cardiomyoplasty in goats with dilated left ventricle.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0231335 Publication Model: Print Cited Medium: Print ISSN: 0012-3692 (Print) Linking ISSN: 00123692 NLM ISO Abbreviation: Chest Subsets: MEDLINE
    • Publication Information:
      Publication: 2016- : New York : Elsevier
      Original Publication: Chicago : American College of Chest Physicians
    • Subject Terms:
      Cardiomyoplasty* ; Hemodynamics* ; Ventricular Function, Left*; Cardiomyopathy, Dilated/*physiopathology; Animals ; Cardiac Output ; Cardiomyopathy, Dilated/surgery ; Female ; Goats ; Hypertrophy, Left Ventricular/physiopathology ; Hypertrophy, Left Ventricular/surgery ; Stroke Volume
    • Abstract:
      Objective: Clinical data have suggested the occurrence of temporary short-term deterioration of the heart following cardiomyoplasty. The purpose of this study was to monitor the short-term hemodynamic effects of cardiomyoplasty in a goat model of a dilated left ventricle, using conductance catheters (ie, pressure-volume loops) and cardiac output measurements.
      Methods: Eight female goats underwent acute cardiomyoplasty 8 to 12 weeks after left ventricular (LV) dilatation was induced by a carotid jugular arteriovenous shunt. The cardiomyoplasty procedure was monitored using a Swan-Ganz catheter for cardiac output measurements and a 12-electrode (dual-field) conductance catheter to LV pressure-volume loops.
      Results: After wrapping the heart with the latissimus dorsi muscle, there was a significant reduction in both cardiac output and LV end-diastolic volume (LVEDV) at 10 min. Partial recovery was observed 45 min later.
      Conclusion: A decrease in both cardiac output and LVEDV was observed following myocardial wrapping. This may explain some of the perioperative and postoperative morbidity and mortality observed following cardiomyoplasty.
    • Publication Date:
      Date Created: 20020515 Date Completed: 20020611 Latest Revision: 20190514
    • Publication Date:
      20231215
    • Accession Number:
      10.1378/chest.121.5.1628
    • Accession Number:
      12006454